Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.38 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.38 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.38 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 2/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL347706 | 0.85 | ACKR3 (0.43) | ACKR3ALDH1A1PRKAA2PRKAB2PRKAG1 | |
| SCHEMBL1019654 | 0.76 | ACKR3 (0.44) | ACKR3ALDH1A1KDM4EHTT | |
| SCHEMBL1018507 | 0.75 | ACKR3 (0.46) | ACKR3ALDH1A1PRKAA2PRKAB2PRKAG1 | |
| SCHEMBL346910 | 0.75 | ALDH1A1 (0.41) | ACKR3ALDH1A1PRKAA2PRKAB2PRKAG1 | |
| SCHEMBL1019797 | 0.75 | FAAH (0.45) | ACKR3ALDH1A1KDM4EHTTDCUN1D1 | |
| Hydrochloric Acid SCHEMBL1019762 | 0.74 | FAAH (0.44) | ACKR3ALDH1A1KDM4EHTTDCUN1D1 | |
| SCHEMBL3690780 | 0.74 | KDM4E (0.47) | ACKR3ALDH1A1KDM4EHTTTDP1 | |
| SCHEMBL12954974 | 0.74 | DRD2 (0.47) | ACKR3DRD4DCUN1D1 | |
| SCHEMBL347099 | 0.74 | PRKAA2 (0.44) | ACKR3PRKAA2PRKAB2PRKAG1PRKAA1 | |
| SCHEMBL1018193 | 0.73 | DCUN1D1 (0.42) | ACKR3ALDH1A1EPHX2KDM4EDCUN1D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8759352-B2 | 1-(4-ureidobenzoyl)piperazine derivatives | MERCK SHARP & DOHME B.V. (NL) | 2014-06-24 | — | — | US | disclosed |
| US-20120015958-A1 | 1-(4-UREIDOBENZOYL)PIPERAZINE DERIVATIVES | N.V. ORGANON (NL) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015958-A1 | 1-(4-UREIDOBENZOYL)PIPERAZINE DERIVATIVES | NPC1, ABCB11, NPC1L1 | ACKR3 1675/4885ALDH1A1 1156/4885PRKAA2 4031/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.