Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | THRA | P10827 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | HMGCR | P04035 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5729791 | 0.86 | CYP2C19 (0.55) | NPC1RAB9AHTTHPGDALDH1A1 | |
| SCHEMBL27669562 | 0.86 | KDM4E (0.55) | NPC1HPGDALDH1A1THRATHRB | |
| SCHEMBL5051445 | 0.86 | GSK3B (0.58) | NPC1RAB9AHTTHPGDALDH1A1 | |
| SCHEMBL31098753 | 0.85 | THRA (0.48) | ALDH1A1THRATHRBHMGCRHSP90AB1 | |
| SCHEMBL27688365 | 0.84 | THRA (0.53) | THRATHRBHMGCRHSP90AB1MAPT | |
| SCHEMBL28800858 | 0.83 | THRA (0.66) | THRATHRBSMN1; SMN2 | |
| SCHEMBL27831620 | 0.83 | THRA (0.43) | RAB9AHTTALDH1A1THRATHRB | |
| SCHEMBL27719541 | 0.82 | THRB (0.45) | NPC1RAB9AALDH1A1THRATHRB | |
| SCHEMBL27811253 | 0.82 | MTNR1A (0.48) | NPC1RAB9AHTTHPGDTHRA | |
| SCHEMBL5914630 | 0.82 | SMN1; SMN2 (0.63) | NPC1RAB9AHTTHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105541738-B | A kind of preparation method of the acetophenone compounds of triazole substitution | 西北师范大学 | 2018-04-06 | — | — | CN | disclosed |
| CN-105229009-B | 2-phenylimidazo [1,2-A ] pyrimidines as imaging agents | 豪夫迈·罗氏有限公司 | 2017-09-29 | — | — | CN | disclosed |
| CN-103221047-A | Compounds and methods | TEMPERO PHARMACEUTICALS INC | 2013-07-24 | — | — | CN | disclosed |
| CN-102670617-B | Application of ibuprofen 2-(2-arylmorpholine-4-yl) ethyl ester in preparation of antidepressant drugs | UNIV HUNAN | 2013-03-20 | — | — | CN | disclosed |
| CN-102670617-A | Application of ibuprofen 2-(2-arylmorpholine-4-yl) ethyl ester in preparation of antidepressant drugs | UNIV HUNAN | 2012-09-19 | — | — | CN | disclosed |
| CN-101636155-A | Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme | ABBOTT LAB | 2010-01-27 | — | — | CN | disclosed |
| US-20100004159-A1 | SUBSTITUTED IMIDAZOLONE DERIVATIVES, PREPARATIONS AND USES | GENFIT (FR) | 2010-01-07 | — | — | US | disclosed |
| US-20100004159-A1 | SUBSTITUTED IMIDAZOLONE DERIVATIVES, PREPARATIONS AND USES | GENFIT (FR) | 2010-01-07 | — | — | US | disclosed |
| US-20100004159-A1 | SUBSTITUTED IMIDAZOLONE DERIVATIVES, PREPARATIONS AND USES | GENFIT (FR) | 2010-01-07 | — | — | US | disclosed |
| CN-101522192-A | Substituted imidazolone derivatives, preparation and uses | GENFIT (FR) | 2009-09-02 | — | — | CN | disclosed |
| US-20090062236-A1 | Programmable genotoxic agents and uses therefor | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2009-03-05 | — | — | US | disclosed |
| WO-2008012470-A2 | SUBSTITUTED IMIDAZOLONE DERIVATIVES, PREPARATION AND USES | GENFIT (FR) | 2008-01-31 | — | — | WO | disclosed |
| WO-2008012470-A2 | SUBSTITUTED IMIDAZOLONE DERIVATIVES, PREPARATION AND USES | GENFIT (FR) | 2008-01-31 | — | — | WO | disclosed |
| US-7169611-B2 | Programmable genotoxic agents and uses therefor | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2007-01-30 | — | — | US | disclosed |
| EP-0758249-B1 | PROGRAMMABLE GENOTOXIC AGENTS AND USES THEREFOR | MASSACHUSETTS INST TECHNOLOGY (US) | 2006-08-02 | — | — | EP | disclosed |
| US-20030220311-A1 | Programmable genotoxic agents and uses therefor | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2003-11-27 | — | — | US | disclosed |
| US-6500669-B1 | FOR SELECTIVELY KILLING A SUBPOPULATION OF CELLS IN A HETEROGENOUS CELL POPULATION; ALKYLATING AGENTS OR HEAVY METAL COORDINATION COMPOUNDS LINKED TO A COMPOUND THAT BINDS TO STEROID RECEPTOR | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2002-12-31 | — | — | US | disclosed |
| US-5879917-A | DESIGNED TO KILL SELECTED CELLS PRESENT IN HETERGENOUS CELL POPULATION; CAUSE SELECTIVE KILLING OF TRANSFORMED CELLS, VIRAL-INFECTED CELLS, ETC. | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1999-03-09 | — | — | US | disclosed |
| EP-0758249-A1 | PROGRAMMABLE GENOTOXIC AGENTS AND USES THEREFOR | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1997-02-19 | — | — | EP | disclosed |
| WO-1995030442-A1 | PROGRAMMABLE GENOTOXIC AGENTS AND USES THEREFOR | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1995-11-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004159-A1 | SUBSTITUTED IMIDAZOLONE DERIVATIVES, PREPARATIONS AND USES | IPO5, PPIP5K2, IPO4 | NPC1 1123/4885RAB9A 1905/4885HTT 321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.