Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7138558 | 0.83 | LMNA (0.57) | L3MBTL1POLBALDH1A1LMNAGAA | |
| SCHEMBL3485703 | 0.80 | PTGDR2 (0.43) | L3MBTL1POLBALDH1A1LMNAGAA | |
| SCHEMBL10993237 | 0.80 | FFAR1 (0.47) | L3MBTL1KMT2AMAPTNPSR1HTR2A | |
| SCHEMBL18570579 | 0.76 | L3MBTL1 (0.46) | L3MBTL1ALDH1A1LMNAGAAKMT2A | |
| SCHEMBL19563647 | 0.75 | SCN8A (0.46) | L3MBTL1ALDH1A1LMNAGAAKMT2A | |
| SCHEMBL19563652 | 0.75 | HTR2A (0.51) | L3MBTL1ALDH1A1LMNAKMT2AMAPT | |
| SCHEMBL18570517 | 0.75 | L3MBTL1 (0.62) | L3MBTL1ALDH1A1LMNAMAPTNPSR1 | |
| SCHEMBL22809589 | 0.75 | SLC6A4 (0.56) | L3MBTL1ALDH1A1LMNAGAAKMT2A | |
| SCHEMBL22809585 | 0.75 | SCN8A (0.48) | L3MBTL1LMNAMAPTATMEPAS1 | |
| SCHEMBL919095 | 0.74 | TEAD1 (0.46) | L3MBTL1POLBALDH1A1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257536-A2 | CYCLIC DIARYL ETHER AS ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009102893-A2 | CYCLIC DIARYL ETHER COMPOUNDS AS ANTAGONISTS OF PROSTAGLANDIN D2 receptors | AMIRA PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |