Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.48 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.40 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3488415 | 0.86 | ALDH1A1 (0.43) | MEN1KMT2AMAP4K4ALDH1A1MAPT | |
| SCHEMBL2944371 | 0.85 | NUDT1 (0.53) | MEN1KMT2AMAP4K4ALDH1A1MAPT | |
| SCHEMBL3487123 | 0.83 | KMT2A (0.44) | MEN1KMT2AMAP4K4ALDH1A1MAPT | |
| SCHEMBL3487024 | 0.80 | MAP4K4 (0.42) | MEN1KMT2AMAP4K4MAPTPOLB | |
| SCHEMBL95212 | 0.75 | SIRT2 (0.41) | KMT2AALDH1A1POLBTDP1NPC1 | |
| SCHEMBL29378197 | 0.75 | SIRT2 (0.41) | KMT2AALDH1A1POLBTDP1NPC1 | |
| SCHEMBL3487431 | 0.75 | MEN1 (0.44) | MEN1KMT2AMAP4K4ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL3391003 | 0.74 | SIRT2 (0.40) | KMT2AALDH1A1POLBTDP1NPC1 | |
| Hydrochloric Acid SCHEMBL4602018 | 0.74 | SIRT2 (0.40) | KMT2AALDH1A1POLBTDP1NPC1 | |
| Hydrochloric Acid SCHEMBL31409347 | 0.74 | SIRT2 (0.40) | KMT2AALDH1A1POLBTDP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2138484-B1 | FUSED BICYCLIC HETEROARYL DERIVATIVES | DAIICHI SANKYO CO LTD (JP) | 2015-08-26 | — | — | EP | disclosed |
| CN-101679298-B | Fused bicyclic heteroaryl derivatives | DAIICHI SANKYO CO LTD | 2013-10-23 | — | — | CN | disclosed |
| US-20130035337-A1 | FUSED BICYCLIC HETEROARYL DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-02-07 | — | — | US | disclosed |
| CN-101679298-A | fused bicyclic heteroaryl derivatives | DAIICHI SANKYO CO LTD | 2010-03-24 | — | — | CN | disclosed |
| US-20100048564-A1 | FUSED BICYCLIC HETEROARYL DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-02-25 | — | — | US | disclosed |
| EP-2138484-A1 | FUSED BICYCLIC HETEROARYL DERIVATIVES | Daiichi Sankyo Company, Limited (JP) | 2009-12-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130035337-A1 | FUSED BICYCLIC HETEROARYL DERIVATIVE | PPARG, GPR119, PPARA | MEN1 4545/4885KMT2A 2465/4885MAP4K4 2382/4885 |
| US-20100048564-A1 | FUSED BICYCLIC HETEROARYL DERIVATIVE | PPARG, GPR119, PPARA | MEN1 4545/4885KMT2A 2465/4885MAP4K4 2382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.