Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 5/20 | 0.33 |
| ▸ | ACHE | P22303 | 5/20 | 0.33 |
| ▸ | F10 | P00742 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.33 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3487078 | 0.86 | MEN1 (0.50) | ALDH1A1SMN1; SMN2MAP4K4KDM4ENUDT1 | |
| SCHEMBL3487123 | 0.82 | KMT2A (0.44) | ALDH1A1SMN1; SMN2MAP4K4KDM4ENUDT1 | |
| SCHEMBL2944371 | 0.81 | NUDT1 (0.53) | ALDH1A1MAP4K4NUDT1MAOAF10 | |
| SCHEMBL3487024 | 0.79 | MAP4K4 (0.42) | SMN1; SMN2MAP4K4KDM4ENUDT1F10 | |
| Orcinol SCHEMBL6424543 | 0.76 | NNMT (0.36) | ALDH1A1SMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL3488287 | 0.76 | POLB (0.44) | ALDH1A1SMN1; SMN2MAOAMEN1KMT2A | |
| SCHEMBL29378197 | 0.74 | SIRT2 (0.41) | ALDH1A1SMN1; SMN2KDM4EKMT2APOLB | |
| SCHEMBL95212 | 0.74 | SIRT2 (0.41) | ALDH1A1SMN1; SMN2KDM4EKMT2APOLB | |
| Hydrochloric Acid SCHEMBL3391003 | 0.73 | SIRT2 (0.40) | ALDH1A1SMN1; SMN2KDM4EKMT2APOLB | |
| Hydrochloric Acid SCHEMBL31409347 | 0.73 | SIRT2 (0.40) | ALDH1A1SMN1; SMN2KDM4EKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2138484-B1 | FUSED BICYCLIC HETEROARYL DERIVATIVES | DAIICHI SANKYO CO LTD (JP) | 2015-08-26 | — | — | EP | disclosed |
| CN-101679298-B | Fused bicyclic heteroaryl derivatives | DAIICHI SANKYO CO LTD | 2013-10-23 | — | — | CN | disclosed |
| US-20130035337-A1 | FUSED BICYCLIC HETEROARYL DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-02-07 | — | — | US | disclosed |
| US-20100048564-A1 | FUSED BICYCLIC HETEROARYL DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-02-25 | — | — | US | disclosed |
| EP-2138484-A1 | FUSED BICYCLIC HETEROARYL DERIVATIVES | Daiichi Sankyo Company, Limited (JP) | 2009-12-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130035337-A1 | FUSED BICYCLIC HETEROARYL DERIVATIVE | PPARG, GPR119, PPARA | ALDH1A1 698/4885SMN1; SMN2 4397/4885MAP4K4 2382/4885 |
| US-20100048564-A1 | FUSED BICYCLIC HETEROARYL DERIVATIVE | PPARG, GPR119, PPARA | ALDH1A1 698/4885SMN1; SMN2 4397/4885MAP4K4 2382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.