Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 9/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 9/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 9/20 | 0.49 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3488750 | 0.80 | PGR (0.47) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL3488809 | 0.80 | ALDH1A1 (0.39) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL3488535 | 0.79 | CDC7 (0.45) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL3489344 | 0.79 | ALDH1A1 (0.38) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL3488964 | 0.79 | MAPK14 (0.42) | MAPK14P2RX7ALDH1A1MAPT | |
| SCHEMBL3488055 | 0.79 | SLC2A1 (0.39) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL3488293 | 0.78 | NR3C2 (0.39) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL3489968 | 0.78 | NR3C2 (0.48) | ALDH1A1MAPT | |
| SCHEMBL3488574 | 0.77 | PTGS2 (0.41) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL3489611 | 0.77 | MAPT (0.52) | MAPK14ALDH1A1KDM4ETSHRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100094000-A1 | PYRAZOLE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-04-15 | — | — | US | disclosed |
| US-20100094000-A1 | PYRAZOLE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-04-15 | — | — | US | disclosed |
| US-20100094000-A1 | PYRAZOLE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100094000-A1 | PYRAZOLE COMPOUNDS | NR3C2, MC2R, NR3C1 | MAPK14 646/4885MAPK13 334/4885MAPK12 521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.