SCHEMBL348979

SCHEMBL348979

O=C(O)Cc1ccc(Cl)cc1F

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KEAP1 Q14145 1/20 0.50
NFE2L2 Q16236 1/20 0.50
ERCC1 P07992 1/20 0.47
ERCC4 Q92889 1/20 0.47
CXCL8 P10145 3/20 0.46
CYP2C9 P11712 1/20 0.46
CHRM1 P11229 1/20 0.46
FFAR1 O14842 1/20 0.44
FFAR4 Q5NUL3 1/20 0.44
AKR1C3 P42330 1/20 0.43
AKR1C2 P52895 1/20 0.43
GRIK1 P39086 1/20 0.43
AKR1B1 P15121 1/20 0.42
PPARG P37231 3/20 0.41
PPARA Q07869 3/20 0.41
TP53 P04637 1/20 0.41
HTR1A P08908 1/20 0.41
HTR2A P28223 1/20 0.41
HTR7 P34969 1/20 0.41
HTR6 P50406 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29434734 1.00 KEAP1 (0.50) KEAP1NFE2L2ERCC1ERCC4CXCL8
SCHEMBL868684 0.86 KEAP1 (0.51) KEAP1NFE2L2ERCC1ERCC4CXCL8
Hydrochloric Acid SCHEMBL1372458 0.85 KEAP1 (0.50) KEAP1NFE2L2ERCC1ERCC4CXCL8
SCHEMBL1488965 0.85 ERCC1 (0.47) ERCC1ERCC4CYP2C9FFAR1FFAR4
SCHEMBL2394432 0.84 KEAP1 (0.53) KEAP1NFE2L2ERCC1ERCC4CXCL8
SCHEMBL19045455 0.83 ERCC1 (0.46) ERCC1ERCC4CYP2C9FFAR1FFAR4
SCHEMBL5266985 0.83 ICMT (0.46) ERCC1ERCC4CYP2C9TP53HTR1A
SCHEMBL19030836 0.83 ERCC1 (0.46) ERCC1ERCC4CYP2C9FFAR1FFAR4
SCHEMBL16041940 0.82 KEAP1 (0.54) KEAP1NFE2L2CXCL8CYP2C9CHRM1
SCHEMBL8359383 0.81 FFAR1 (0.64) FFAR1FFAR4PPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 257 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3114715-B1 P-DOPING CROSS-LINKING OF ORGANIC HOLE TRANSPORTERS SIEMENS AG (DE) 2019-10-30 EP claimed
EP-3114715-A1 P-DOPING CROSS-LINKING OF ORGANIC HOLE TRANSPORTERS Siemens Aktiengesellschaft (DE) 2017-01-11 EP claimed
US-12599587-B2 Chlorinated tetralin compounds and pharmaceutical compositions SPRINGWORKS THERAPEUTICS, INC. (US) 2026-04-14 US disclosed
US-20260035362-A1 GLP-1R AGONISTS AND USES THEREOF QILU REGOR THERAPEUTICS INC (CN) 2026-02-05 US disclosed
US-20260034099-A1 CHLORINATED TETRALIN COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS SPRINGWORKS THERAPEUTICS INC (US) 2026-02-05 US disclosed
US-12365670-B2 GLP-IR agonists and uses thereof QILU REGOR THERAPEUTICS INC. (CN) 2025-07-22 US disclosed
US-20250185502-A1 ORGANIC OPTOELECTRONIC COMPONENT, ORGANIC FUNCTIONAL LAYER, AND METHOD FOR PRODUCING AN OPTOELECTRONIC COMPONENT OSRAM OLED GMBH (DE) 2025-06-05 US disclosed
US-12302747-B2 Optoelectronic component, organic functional layer, and method for producing an optoelectronic component OSRAM OLED GMBH (DE) 2025-05-13 US disclosed
US-20250115606-A1 HETEROCYCLIC GLP-1 AGONISTS GASHERBRUM BIO, INC. 2025-04-10 US disclosed
US-12221442-B2 Heterocyclic GLP-1 agonists GASHERBRUM BIO, INC. (US) 2025-02-11 US disclosed
EP-4193399-B1 ELECTRONIC DEVICE MERCK PATENT GMBH (DE) 2025-01-29 EP disclosed
EP-1894911-A1 VITAMIN D-LIKE COMPOUND CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2008-03-05 EP disclosed
CN-101107226-A Phenoxyacetic acid derivatives useful for treating respiratory diseases ASTRAZENECA AB (SE) 2008-01-16 CN disclosed
EP-1817282-A1 PHENOXYACETIC ACID DERIVATIVES USEFUL FOR TREATING RESPIRATORY DISEASES AstraZeneca AB (SE) 2007-08-15 EP disclosed
WO-2006056752-A1 PHENOXYACETIC ACID DERIVATIVES USEFUL FOR TREATING RESPIRATORY DISEASES ASTRAZENECA AB (SE) 2006-06-01 WO disclosed
EP-0885885-B1 PYRIDONE DERIVATIVES AND HERBICIDES KUMIAI CHEMICAL INDUSTRY CO (JP) 2006-01-04 EP disclosed
US-6472348-B1 Pyridone derivatives and herbicides KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 2002-10-29 US disclosed
US-6265349-B1 Pyridone derivatives and herbicides KUMIAI CHEMICAL INDUSTRY CO., LTD (JP) 2001-07-24 US disclosed
US-6048823-A Pyridone derivatives and herbicides KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 2000-04-11 US disclosed
EP-0885885-A1 PYRIDONE DERIVATIVES AND HERBICIDES KumaiI Chemical Industry Co., Ltd. (JP) 1998-12-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260035362-A1 GLP-1R AGONISTS AND USES THEREOF GLP1R, GPR119, IAPP KEAP1 3989/4885NFE2L2 2653/4885ERCC1 4744/4885
US-12221442-B2 Heterocyclic GLP-1 agonists GLP1R, GIPR, GCGR KEAP1 3894/4885NFE2L2 4095/4885ERCC1 4584/4885
US-20260034099-A1 CHLORINATED TETRALIN COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS BACE1, BACE2, DSG1 KEAP1 3615/4885NFE2L2 1631/4885ERCC1 538/4885
US-12365670-B2 GLP-IR agonists and uses thereof GLP1R, GPR119, GIPR KEAP1 3195/4885NFE2L2 1758/4885ERCC1 4834/4885
US-20250115606-A1 HETEROCYCLIC GLP-1 AGONISTS GLP1R, GIPR, GCGR KEAP1 3894/4885NFE2L2 4095/4885ERCC1 4584/4885
US-12599587-B2 Chlorinated tetralin compounds and pharmaceutical compositions CLIC1, CLCN2, CSNK1D KEAP1 4698/4885NFE2L2 2518/4885ERCC1 2887/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.