Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.38 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
| ▸ | PARP14 | Q460N5 | 6/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KLK7 | P49862 | 1/20 | 0.36 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7869140 | 0.81 | KMT2A (0.56) | MAPTKMT2AMEN1HTTPOLB | |
| SCHEMBL21664524 | 0.80 | CDYL (0.49) | PSMB8PSMB5TDP1KDM4E | |
| SCHEMBL20562275 | 0.79 | EGFR (0.56) | ERAP1PARP14MAPTKMT2AMEN1 | |
| SCHEMBL5409417 | 0.76 | PSMB8 (0.41) | PSMB8PSMB5POLBALDH1A1 | |
| SCHEMBL573807 | 0.76 | KDM4E (0.54) | PARP14MAPTKMT2AMEN1EGFR | |
| SCHEMBL30421102 | 0.74 | EGFR (0.55) | PARP14MAPTEGFRSRCJAK2 | |
| SCHEMBL1233101 | 0.74 | CYP1A2 (0.62) | MAPTKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL27535389 | 0.73 | NAAA (0.58) | MAPTKMT2AMEN1TDP1ALDH1A1 | |
| SCHEMBL17781261 | 0.71 | SMN1; SMN2 (0.37) | PSMB8PSMB5MAPTKMT2AMEN1 | |
| SCHEMBL436079 | 0.71 | TDP1 (0.54) | PSMB8PSMB5MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304520-B2 | Labeled fusion protein | THE UNIVERSITY OF TOKYO (JP) | 2012-11-06 | — | — | US | disclosed |
| US-20100105882-A1 | MOLECULAR MODULE | THE UNIVERSITY OF TOKYO (JP) | 2010-04-29 | — | — | US | disclosed |
| EP-2098538-A1 | MOLECULAR MODULE | The University of Tokyo (JP) | 2009-09-09 | — | — | EP | disclosed |
| US-20050118605-A9 | Oligomeric compounds having modified bases for binding to adenine and guanine and their use in gene modulation | ISIS PHARMACEUTICALS, INC. | 2005-06-02 | — | — | US | disclosed |
| US-20050037370-A1 | Oligomeric compounds having modified bases for binding to adenine and guanine and their use in gene modulation | BAKER BRENDA F (US) | 2005-02-17 | — | — | US | disclosed |
| US-20050032069-A1 | Oligomeric compounds having modified bases for binding to adenine and guanine and their use in gene modulation | ISIS PHARMACEUTICALS, INC. | 2005-02-10 | — | — | US | disclosed |
| WO-2004044245-A1 | OLIGOMERIC COMPOUNDS HAVING MODIFIED BASES FOR BINDING TO ADENINE AND GUANINE AND THEIR USE IN GENE MODULATION | ISIS PHARMACEUTICALS, INC. (US) | 2004-05-27 | — | — | WO | disclosed |
| EP-0644890-B1 | OLIGONUCLEOTIDE-POLYAMIDE CONJUGATES | HOWARD FLOREY INST OF BR EX PH (AU) | 2001-12-05 | — | — | EP | disclosed |
| EP-0383803-B1 | OLIGONUCLEOTIDE-POLYAMIDE CONJUGATES | HOWARD FLOREY INST OF (AU) | 2000-05-03 | — | — | EP | disclosed |
| EP-0972779-A2 | Oligonucleotide-polyamide conjugates | HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE (AU) | 2000-01-19 | — | — | EP | disclosed |
| EP-0644890-A4 | OLIGONUCLEOTIDE-POLYAMIDE CONJUGATES. | FLOREY HOWARD INST (AU) | 1996-03-27 | — | — | EP | disclosed |
| EP-0644890-A1 | OLIGONUCLEOTIDE-POLYAMIDE CONJUGATES | HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE (AU) | 1995-03-29 | — | — | EP | disclosed |
| EP-0366685-B1 | NUCLEOSIDE DERIVATIVES | FLOREY HOWARD INST (AU) | 1994-10-19 | — | — | EP | disclosed |
| WO-1993024511-A1 | OLIGONUCLEOTIDE-POLYAMIDE CONJUGATES | HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE (AU) | 1993-12-09 | — | — | WO | disclosed |
| EP-0366685-A4 | NUCLEOSIDE DERIVATIVES | — | 1991-03-20 | — | — | EP | disclosed |
| EP-0383803-A4 | OLIGONUCLEOTIDE-POLYAMIDE CONJUGATES | — | 1991-03-20 | — | — | EP | disclosed |
| EP-0383803-A1 | OLIGONUCLEOTIDE-POLYAMIDE CONJUGATES | HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE (AU) | 1990-08-29 | — | — | EP | disclosed |
| EP-0366685-A1 | NUCLEOSIDE DERIVATIVES. | FLOREY HOWARD INST (AU) | 1990-05-09 | — | — | EP | disclosed |
| WO-1989003849-A1 | OLIGONUCLEOTIDE-POLYAMIDE CONJUGATES | HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY (AU) | 1989-05-05 | — | — | WO | disclosed |
| WO-1988010264-A1 | NUCLEOSIDE DERIVATIVES | HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY (AU) | 1988-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050037370-A1 | Oligomeric compounds having modified bases for binding to adenine and guanine and their use in gene modulation | RNMT, RRBP1, G3BP1 | ERAP1 2591/4885PSMB8 780/4885PSMB5 1466/4885 |
| US-20050118605-A9 | Oligomeric compounds having modified bases for binding to adenine and guanine and their use in gene modulation | RNMT, RRBP1, G3BP1 | ERAP1 2591/4885PSMB8 780/4885PSMB5 1466/4885 |
| US-20050032069-A1 | Oligomeric compounds having modified bases for binding to adenine and guanine and their use in gene modulation | RNMT, RRBP1, G3BP1 | ERAP1 2591/4885PSMB8 780/4885PSMB5 1466/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.