Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 2/20 | 0.53 |
| ▸ | CASP3 | P42574 | 2/20 | 0.53 |
| ▸ | CASP9 | P55211 | 2/20 | 0.53 |
| ▸ | CASP4 | P49662 | 1/20 | 0.53 |
| ▸ | CASP5 | P51878 | 1/20 | 0.53 |
| ▸ | CASP6 | P55212 | 1/20 | 0.53 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.53 |
| ▸ | CASP10 | Q92851 | 1/20 | 0.53 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.53 |
| ▸ | CASP7 | P55210 | 1/20 | 0.53 |
| ▸ | CTSK | P43235 | 8/20 | 0.52 |
| ▸ | CTSB | P07858 | 3/20 | 0.51 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3491057 | 0.84 | PTPN1 (0.47) | CASP1CASP3CASP9CASP4CASP5 | |
| SCHEMBL3490826 | 0.84 | CASP3 (0.73) | CASP1CASP3CASP9CASP4CASP5 | |
| SCHEMBL158671 | 0.84 | CASP1 (0.56) | CASP1CASP3CASP9PSMB1CASP7 | |
| SCHEMBL7168373 | 0.84 | CASP1 (0.58) | CASP1CASP3CASP9PSMB1CASP7 | |
| SCHEMBL27533999 | 0.82 | CTSK (0.70) | CTSKCTSBCTSLCAPN1 | |
| SCHEMBL4424261 | 0.82 | CTSK (0.70) | CTSKCTSBCTSLCAPN1 | |
| SCHEMBL28399571 | 0.81 | CASP3 (0.70) | CASP1CASP3CASP9CASP4CASP5 | |
| SCHEMBL7267407 | 0.80 | PSMB1 (0.70) | PSMB1CTSKCTSBCTSLCAPN1 | |
| SCHEMBL29362585 | 0.80 | CASP3 (0.76) | CASP1CASP3CASP9CASP4CASP5 | |
| SCHEMBL30541131 | 0.80 | CASP3 (0.61) | CASP1CASP3CASP9CASP4CASP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008079408-A1 | A ZEBRAFISH BASED SCREEN FOR AGENTS WITH ABILITY TO PREVENT CELL DEATH | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2008-07-03 | — | — | WO | claimed |
| US-20160151403-A1 | SMALL MOLECULE MODULATORS OF P53 FAMILY SIGNALING | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2016-06-02 | — | — | US | disclosed |
| US-20100047783-A1 | SMALL MOLECULE MODULATORS OF P53 FAMILY SIGNALING | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2010-02-25 | — | — | US | disclosed |
| WO-2008079408-A1 | A ZEBRAFISH BASED SCREEN FOR AGENTS WITH ABILITY TO PREVENT CELL DEATH | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2008-07-03 | — | — | WO | disclosed |
| WO-2008011008-A1 | BIOLUMINESCENT IMAGING OF TRAIL INDUCED APOPTOSIS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2008-01-24 | — | — | WO | disclosed |
| US-20070048726-A1 | Methods and Compositions for the Control of Molecular-Based Cell Death During Preservation of Cells, Tissues or Organs in a Gel-Like State | BIOLIFE SOLUTIONS, INC. (US) | 2007-03-01 | — | — | US | disclosed |
| US-6921633-B2 | Methods and compositions for the preservation of cells, tissues or organs in the vitreous state | BIOLIFE SOLUTIONS INCORPORATED (US) | 2005-07-26 | — | — | US | disclosed |
| WO-2004046308-A2 | METHODS AND COMPOSITIONS FOR THE PRESERVATION OF CELLS, TISSUES OR ORGANS IN THE VITREOUS STATE | BIOLIFE SOLUTIONS, INC. (US) | 2004-06-03 | — | — | WO | disclosed |
| US-20040096813-A1 | Methods and compositions for the preservation of cells, tissues or organs in the vitreous state | BIOLIFE SOLUTIONS, INC. | 2004-05-20 | — | — | US | disclosed |