Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 5/20 | 0.58 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.57 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.57 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.42 |
| ▸ | IL1B | P01584 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PTPRF | P10586 | 1/20 | 0.39 |
| ▸ | ACP1 | P24666 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 2/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | NT5E | P21589 | 1/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.36 |
| ▸ | F3 | P13726 | 1/20 | 0.35 |
| ▸ | PNLIP | P16233 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13401510 | 1.00 | PTPN1 (0.58) | PTPN1HSD11B1HSD11B2GP6IL1B | |
| SCHEMBL3492708 | 1.00 | PTPN1 (0.58) | PTPN1HSD11B1HSD11B2GP6IL1B | |
| SCHEMBL13401523 | 0.77 | PTPN1 (0.56) | PTPN1HSD11B1HSD11B2BCHEACHE | |
| Phyllocladene SCHEMBL156928 | 0.77 | HSD11B1 (0.72) | PTPN1HSD11B1HSD11B2BCHEACHE | |
| Phyllocladene SCHEMBL1006869 | 0.77 | HSD11B1 (0.72) | PTPN1HSD11B1HSD11B2BCHEACHE | |
| Phyllocladene SCHEMBL29388334 | 0.77 | HSD11B1 (0.72) | PTPN1HSD11B1HSD11B2BCHEACHE | |
| Phyllocladene SCHEMBL1006868 | 0.77 | HSD11B1 (0.72) | PTPN1HSD11B1HSD11B2BCHEACHE | |
| Phyllocladene SCHEMBL29437839 | 0.77 | HSD11B1 (0.72) | PTPN1HSD11B1HSD11B2BCHEACHE | |
| SCHEMBL267552 | 0.74 | PTPN1 (0.65) | PTPN1HSD11B1HSD11B2BCHEACHE | |
| SCHEMBL29546419 | 0.74 | PTPN1 (0.65) | PTPN1HSD11B1HSD11B2BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100099640-A1 | TISSUE DEGENERATION PROTECTION | GEUNS JOANNES | 2010-04-22 | — | — | US | disclosed |
| EP-2155769-A2 | TISSUE DEGENERATION PROTECTION | Katholieke Universiteit Leuven (BE) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008134828-A2 | TISSUE DEGENERATION PROTECTION | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2008-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100099640-A1 | TISSUE DEGENERATION PROTECTION | SORD, CASP3, TXNRD2 | PTPN1 3492/4885HSD11B1 187/4885HSD11B2 114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.