Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3494815 | 0.86 | NR4A2 (0.46) | MRGPRX4NR4A2MAOBMAPTPTGER4 | |
| SCHEMBL3491847 | 0.81 | NOTUM (0.51) | MAPTSMN1; SMN2NOTUMALDH1A1NPSR1 | |
| SCHEMBL3493113 | 0.78 | NOTUM (0.53) | MRGPRX4NR4A2MAOBMAPTPTGER4 | |
| SCHEMBL3493945 | 0.78 | PTGER1 (0.42) | MRGPRX4MAPTPTGER4ALKBH1 | |
| SCHEMBL3493854 | 0.76 | DCTPP1 (0.46) | MAPTSMN1; SMN2TSHRNOTUMALDH1A1 | |
| SCHEMBL3495799 | 0.75 | JAK2 (0.55) | MRGPRX4MAOBMAPTJAK2JAK3 | |
| SCHEMBL3386778 | 0.72 | KDM4E (0.73) | MAPTSMN1; SMN2SRD5A2ALDH1A1NPSR1 | |
| SCHEMBL4089863 | 0.70 | PTGER4 (0.59) | MRGPRX4NR4A2MAOBPTGER4 | |
| SCHEMBL4638788 | 0.70 | MRGPRX4 (0.51) | MRGPRX4NR4A2MAOBPTGER4JAK2 | |
| SCHEMBL3494813 | 0.68 | NOTUM (0.48) | MRGPRX4NR4A2MAOBMAPTJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100121048-A1 | Cyclic Amine Compound and Use Thereof for the Prophylaxis or Treatment of Hypertension | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100121048-A1 | Cyclic Amine Compound and Use Thereof for the Prophylaxis or Treatment of Hypertension | REN, AGTR1, AGTR2 | MRGPRX4 297/4885NR4A2 1564/4885MAOB 49/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.