Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.59 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 3/20 | 0.59 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.48 |
| ▸ | MIF | P14174 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7262478 | 1.00 | ESR1 (0.59) | ESR1ESR2TSHRADRB1ADRA1A | |
| SCHEMBL9256909 | 1.00 | ESR1 (0.59) | ESR1ESR2TSHRADRB1ADRA1A | |
| SCHEMBL8944137 | 0.79 | ADRB1 (0.48) | ESR1ESR2TSHRADRB1ADRA1A | |
| SCHEMBL6966592 | 0.79 | ADRB1 (0.48) | ESR1ESR2TSHRADRB1ADRA1A | |
| SCHEMBL6691199 | 0.78 | TSHR (0.57) | ESR1ESR2TSHRADRB1ADRB2 | |
| SCHEMBL198178 | 0.78 | TSHR (0.57) | ESR1ESR2TSHRSLC6A3ALDH1A1 | |
| SCHEMBL2162950 | 0.78 | TSHR (0.57) | ESR1ESR2TSHRLMNAALDH1A1 | |
| SCHEMBL21807151 | 0.78 | TSHR (0.57) | ESR1ESR2TSHRHIF1ARAB9A | |
| SCHEMBL7767485 | 0.78 | ESR1 (0.58) | ESR1ESR2TSHRADRB1ADRA1A | |
| SCHEMBL9176673 | 0.78 | TSHR (0.57) | ESR1ESR2TSHRGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137636-A1 | IDENTIFICATION OF A NITRILASE FROM B. JAPONICUM BY RATIONAL GENOME MINING AND METHODS OF USE | SOUTHERN METHODIST UNIVERSITY | 2010-06-03 | — | — | US | disclosed |
| US-7622585-B2 | Phenylglycinamide derivatives useful as anticoagulants | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-11-24 | — | — | US | disclosed |
| US-7456195-B2 | Phenylglycinamide and pyridylglycinamide derivatives useful as anticoagulants | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-11-25 | — | — | US | disclosed |
| US-20070178575-A1 | Identification Of A Nitrilase From B. Japonicum By Rational Genome Mining And Methods Of Use | SOUTHERN METHODIST UNIVERSITY | 2007-08-02 | — | — | US | disclosed |
| US-5008192-A | Enzymatic process for the preparation of optically active cyanohydrins | KERNFORSCHUNGSANLAGE JUELICH GMBH (DE) | 1991-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137636-A1 | IDENTIFICATION OF A NITRILASE FROM B. JAPONICUM BY RATIONAL GENOME MINING AND METHODS OF USE | BLVRB, BBOX1, GGH | ESR1 2303/4885ESR2 2628/4885TSHR 4014/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.