Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.45 |
| ▸ | CTSK | P43235 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14040614 | 0.87 | SMN1; SMN2 (0.57) | FAAHSMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL844472 | 0.87 | SMN1; SMN2 (0.57) | FAAHSMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL4385673 | 0.85 | SMN1; SMN2 (0.51) | FAAHSMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL27648565 | 0.85 | SMN1; SMN2 (0.51) | FAAHSMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL9848391 | 0.84 | SMN1; SMN2 (0.53) | FAAHSMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL9848476 | 0.84 | SMN1; SMN2 (0.53) | FAAHSMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL8121337 | 0.81 | SMN1; SMN2 (0.52) | FAAHSMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL4651068 | 0.81 | FAAH (0.47) | FAAHSMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL8382243 | 0.80 | FAAH (0.46) | FAAHSMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL3630691 | 0.80 | SMN1; SMN2 (0.51) | FAAHSMN1; SMN2NPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8361968-B2 | Metastin derivatives and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-01-29 | — | — | US | disclosed |
| US-20120015868-A1 | Metastin derivatives and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-01-19 | — | — | US | disclosed |
| US-20090318365-A1 | METASTIN DERIVATIVES AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-12-24 | — | — | US | disclosed |
| EP-2113513-A2 | Metastin derivatives and use thereof | Takeda Pharmaceutical Company Limited (JP) | 2009-11-04 | — | — | EP | disclosed |
| EP-1758932-A2 | METASTIN DERIVATIVES AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2007-03-07 | — | — | EP | disclosed |
| US-20060241051-A1 | Metastin derivatives and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-10-26 | — | — | US | disclosed |
| WO-2006001499-A2 | METASTIN DERIVATIVES AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015868-A1 | Metastin derivatives and use thereof | MET, HGFAC, HGF | FAAH 3818/4885SMN1; SMN2 2477/4885NPC1 2592/4885 |
| US-20090318365-A1 | METASTIN DERIVATIVES AND USE THEREOF | MET, HGF, HGFAC | FAAH 3861/4885SMN1; SMN2 2629/4885NPC1 2676/4885 |
| US-20060241051-A1 | Metastin derivatives and use thereof | MET, HGFAC, HGF | FAAH 3818/4885SMN1; SMN2 2477/4885NPC1 2592/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.