Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.57 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.57 |
| ▸ | LEF1 | Q9UJU2 | 1/20 | 0.56 |
| ▸ | PLD2 | O14939 | 1/20 | 0.56 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.56 |
| ▸ | MMP13 | P45452 | 1/20 | 0.52 |
| ▸ | MAOA | P21397 | 2/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PRNP | P04156 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5087408 | 0.84 | LEF1 (0.59) | LEF1PLD2PLD1MMP13MAOA | |
| SCHEMBL3498709 | 0.83 | EGFR (0.64) | EGFRPIK3CAPLD2PLD1MMP13 | |
| SCHEMBL19885734 | 0.81 | LEF1 (0.61) | EGFRPIK3CALEF1PLD2PLD1 | |
| SCHEMBL5087407 | 0.81 | LEF1 (0.55) | LEF1PLD2PLD1MMP13KDM4E | |
| SCHEMBL6619949 | 0.81 | LEF1 (0.81) | LEF1PLD2PLD1MMP13KDM4E | |
| SCHEMBL23486667 | 0.80 | MMP13 (0.51) | LEF1MMP13KDM4ETP53NPC1 | |
| SCHEMBL15623149 | 0.80 | PLD2 (0.70) | EGFRPIK3CAPLD2PLD1MMP13 | |
| SCHEMBL19901406 | 0.80 | PLD2 (0.66) | EGFRPIK3CALEF1PLD2PLD1 | |
| SCHEMBL15224033 | 0.78 | EGFR (0.57) | EGFRPIK3CAPLD2PLD1MMP13 | |
| SCHEMBL3246114 | 0.78 | HRH3 (0.51) | LEF1MMP13KDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461117-B2 | Chemical linkers and cleavable substrates and conjugates thereof | MEDAREX, INC. (US) | 2013-06-11 | — | — | US | disclosed |
| US-8461117-B2 | Chemical linkers and cleavable substrates and conjugates thereof | MEDAREX, INC. (US) | 2013-06-11 | — | — | US | disclosed |
| US-20100145036-A1 | CHEMICAL LINKERS AND CLEAVABLE SUBSTRATES AND CONJUGATES THEREOF | MEDAREX, INC. (US) | 2010-06-10 | — | — | US | disclosed |
| US-20100145036-A1 | CHEMICAL LINKERS AND CLEAVABLE SUBSTRATES AND CONJUGATES THEREOF | MEDAREX, INC. (US) | 2010-06-10 | — | — | US | disclosed |
| US-20100145036-A1 | CHEMICAL LINKERS AND CLEAVABLE SUBSTRATES AND CONJUGATES THEREOF | MEDAREX, INC. (US) | 2010-06-10 | — | — | US | disclosed |
| WO-2008083312-A2 | CHEMICAL LINKERS AND CLEAVABLE SUBSTRATES AND CONJUGATES THEREOF | MEDAREX, INC. (US) | 2008-07-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100145036-A1 | CHEMICAL LINKERS AND CLEAVABLE SUBSTRATES AND CONJUGATES THEREOF | XIAP, ADAM8, CLSPN | EGFR 769/4885PIK3CA 3739/4885LEF1 4754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.