Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LEF1 | Q9UJU2 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.48 |
| ▸ | SCN4A | P35499 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | PRNP | P04156 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PLD2 | O14939 | 1/20 | 0.46 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | PYGL | P06737 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6617197 | 0.88 | LEF1 (0.58) | LEF1KDM4EMMP13TP53NPC1 | |
| SCHEMBL3494717 | 0.88 | HRH4 (0.51) | LEF1KDM4EMMP13TP53NPC1 | |
| SCHEMBL5896865 | 0.85 | LEF1 (0.54) | LEF1KDM4EMMP13TP53SCN3A | |
| SCHEMBL3497422 | 0.84 | EGFR (0.57) | LEF1KDM4EMMP13TP53NPC1 | |
| SCHEMBL6619949 | 0.83 | LEF1 (0.81) | LEF1KDM4EMMP13TP53NPC1 | |
| SCHEMBL5087407 | 0.83 | LEF1 (0.55) | LEF1KDM4EMMP13TP53NPC1 | |
| SCHEMBL5897662 | 0.82 | NHERF1 (0.56) | KDM4ETP53NPC1RAB9ARXFP1 | |
| SCHEMBL23486667 | 0.80 | MMP13 (0.51) | LEF1KDM4EMMP13TP53NPC1 | |
| SCHEMBL29830077 | 0.79 | LEF1 (0.67) | LEF1KDM4EMMP13TP53NPC1 | |
| SCHEMBL21278088 | 0.78 | NPC1 (0.47) | KDM4ETP53NPC1RAB9ARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7329760-B2 | CC-1065 analog synthesis | IMMUNOGEN INC. (US) | 2008-02-12 | — | — | US | disclosed |
| US-7329760-B2 | CC-1065 analog synthesis | IMMUNOGEN INC. (US) | 2008-02-12 | — | — | US | disclosed |
| EP-1492766-B1 | IMPROVED CC-1065 ANALOG SYNTHESIS | IMMUNOGEN INC (US) | 2007-05-02 | — | — | EP | disclosed |
| EP-1492766-B1 | IMPROVED CC-1065 ANALOG SYNTHESIS | IMMUNOGEN INC (US) | 2007-05-02 | — | — | EP | disclosed |
| EP-1492766-A4 | IMPROVED CC-1065 ANALOG SYNTHESIS | IMMUNOGEN INC (US) | 2005-12-14 | — | — | EP | disclosed |
| EP-1492766-A1 | IMPROVED CC-1065 ANALOG SYNTHESIS | Immunogen, Inc. (US) | 2005-01-05 | — | — | EP | disclosed |
| WO-2003087055-A1 | IMPROVED CC-1065 ANALOG SYNTHESIS | IMMUNOGEN, INC. (US) | 2003-10-23 | — | — | WO | disclosed |
| US-20030195365-A1 | CC-1065 analog synthesis | IMMUNOGEN INC. | 2003-10-16 | — | — | US | disclosed |
| US-6534660-B1 | Halogenation, alkylation and ring-closure of protected 2-amino-4-hydroxynaphthalene under suitable conditions to provide desired racemate, isolating (-) isomer, removing protecting groups | IMMUNOGEN, INC. | 2003-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030195365-A1 | CC-1065 analog synthesis | DCUN1D5, DCUN1D1, DBN1 | LEF1 1682/4885KDM4E 682/4885MMP13 4316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.