SCHEMBL3498513

SCHEMBL3498513

O=C(O)c1cn2cccc(OCc3ccc(Cl)cc3)c2n1

nearest known ligand 0.47

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PTGER1 P34995 9/20 0.47
PPARG P37231 1/20 0.44
HPGD P15428 1/20 0.43
RXRA P19793 1/20 0.43
RXRB P28702 1/20 0.43
RHEB Q15382 1/20 0.42
XDH P47989 1/20 0.42
NR4A2 P43354 2/20 0.42
MRGPRX4 Q96LA9 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11096196 0.90 ATP4A (0.50) PTGER1RXRARXRB
SCHEMBL3498584 0.85 KDM4E (0.49) PTGER1PPARGHPGD
SCHEMBL2194287 0.80 PPARG (0.50) PPARG
SCHEMBL3498742 0.78 GPR34 (0.54) PPARG
SCHEMBL3498741 0.78 GPR34 (0.54) PPARG
SCHEMBL7274305 0.78 PSEN1 (0.48) PTGER1
SCHEMBL11070583 0.77 KDM4E (0.52) HPGD
SCHEMBL3499330 0.76 PPARG (0.47) PPARG
SCHEMBL1201345 0.75 PTGS1 (0.50) HPGD
SCHEMBL11094768 0.75 KDM4E (0.50) HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100130737-A1 Regulating Agent of GPR34 Receptor Function TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-05-27 US disclosed
US-20100130737-A1 Regulating Agent of GPR34 Receptor Function TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-05-27 US disclosed
EP-1849465-A1 AGENT FOR CONTROLLING FUNCTION OF GPR34 RECEPTOR Takeda Pharmaceutical Company Limited (JP) 2007-10-31 EP disclosed
EP-1849465-A1 AGENT FOR CONTROLLING FUNCTION OF GPR34 RECEPTOR Takeda Pharmaceutical Company Limited (JP) 2007-10-31 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100130737-A1 Regulating Agent of GPR34 Receptor Function GPR34, GPR4, GPR6 PTGER1 697/4885PPARG 189/4885HPGD 1550/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.