SCHEMBL3499281

SCHEMBL3499281

O=C(O)c1nc2ccc(-c3ccc(Cl)cc3)cn2c1Cl

nearest known ligand 0.48

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
SLC2A2 P11168 2/20 0.48
SLC2A1 P11166 13/20 0.46
EGLN1 Q9GZT9 2/20 0.43
TOP2A P11388 1/20 0.43
ALDH1A1 P00352 1/20 0.42
ALDH1A3 P47895 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3499390 0.80 SLC2A2 (0.58) SLC2A2SLC2A1
SCHEMBL9923914 0.78 KDM4E (0.51) ALDH1A1
SCHEMBL9893259 0.75 USP7 (0.43) SLC2A1ALDH1A1
SCHEMBL3498373 0.74 CDH1 (0.50) SLC2A2SLC2A1ALDH1A1
SCHEMBL312556 0.73 EPHB3 (0.56) EGLN1
SCHEMBL9924041 0.72 ALDH1A1 (0.50) ALDH1A1
SCHEMBL9924007 0.71 PTGS1 (0.66) ALDH1A1
SCHEMBL3498537 0.71 EGLN1 (0.67) EGLN1ALDH1A1ALDH1A3
Hydrochloric Acid SCHEMBL28455052 0.70 PTGS1 (0.64) ALDH1A1
SCHEMBL16463073 0.70 GABRA2 (0.49) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100130737-A1 Regulating Agent of GPR34 Receptor Function TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-05-27 US disclosed
US-20100130737-A1 Regulating Agent of GPR34 Receptor Function TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-05-27 US disclosed
EP-1849465-A1 AGENT FOR CONTROLLING FUNCTION OF GPR34 RECEPTOR Takeda Pharmaceutical Company Limited (JP) 2007-10-31 EP disclosed
EP-1849465-A1 AGENT FOR CONTROLLING FUNCTION OF GPR34 RECEPTOR Takeda Pharmaceutical Company Limited (JP) 2007-10-31 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100130737-A1 Regulating Agent of GPR34 Receptor Function GPR34, GPR4, GPR6 SLC2A2 1403/4885SLC2A1 1193/4885EGLN1 1231/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.