SCHEMBL3499282

SCHEMBL3499282

CC(C)(C)OC(=O)NC(=O)C(N)Cc1ccc(OCc2ccccc2)cc1

nearest known ligand 0.54

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 8/20 0.54
BCL2 P10415 1/20 0.54
LNPEP Q9UIQ6 3/20 0.53
PTPN1 P18031 1/20 0.50
LAP3 P28838 1/20 0.50
YAP1 P46937 2/20 0.48
PPARG P37231 1/20 0.48
MMP9 P14780 1/20 0.47
MMP8 P22894 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4420857 0.89 ATM (0.55) LTA4H
SCHEMBL7806363 0.85 LTA4H (0.56) LTA4HBCL2LNPEPPTPN1LAP3
SCHEMBL7338836 0.84 LTA4H (0.65) LTA4HLNPEPLAP3PPARG
SCHEMBL7339057 0.84 LTA4H (0.65) LTA4HLNPEPLAP3PPARG
SCHEMBL7338844 0.84 LTA4H (0.65) LTA4HLNPEPLAP3PPARG
SCHEMBL2860639 0.83 LTA4H (0.61) LTA4HLNPEPLAP3PPARG
SCHEMBL5832735 0.83 LTA4H (0.61) LTA4HLNPEPLAP3PPARG
Hydrochloric Acid SCHEMBL5832752 0.82 LTA4H (0.60) LTA4HLNPEPLAP3PPARG
Hydrochloric Acid SCHEMBL5832756 0.82 LTA4H (0.60) LTA4HLNPEPLAP3PPARG
SCHEMBL7281929 0.82 MMP9 (0.63) LTA4HLNPEPLAP3PPARGMMP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100130737-A1 Regulating Agent of GPR34 Receptor Function TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-05-27 US disclosed
EP-1849465-A1 AGENT FOR CONTROLLING FUNCTION OF GPR34 RECEPTOR Takeda Pharmaceutical Company Limited (JP) 2007-10-31 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100130737-A1 Regulating Agent of GPR34 Receptor Function GPR34, GPR4, GPR6 LTA4H 1788/4885BCL2 2066/4885LNPEP 3033/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.