Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3518012 | 0.80 | SCN1A (0.44) | POLBMAPK1 | |
| SCHEMBL3515736 | 0.74 | ACP1 (0.47) | ALDH1A1MAPTRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL3515097 | 0.74 | SMN1; SMN2 (0.48) | P2RX7CYP3A4CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL3516223 | 0.73 | BACE1 (0.49) | MAPTKDM4EHSD17B10 | |
| SCHEMBL3516034 | 0.73 | AURKA (0.43) | ALDH1A1MAPTRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL3517441 | 0.72 | PIK3CA (0.49) | CYP3A4KDM4E | |
| SCHEMBL3514363 | 0.71 | RAB9A (0.47) | ALDH1A1MAPTRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL3516717 | 0.71 | KDM4E (0.43) | CYP3A4ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL3514723 | 0.71 | KDM4E (0.43) | CYP3A4ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL3514910 | 0.71 | KDM4E (0.43) | CYP3A4ALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | MERCK SHARP & DOHME CORP. | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | RNASEH1, RNASE1, RNASEL | P2RX7 3719/4885CYP3A4 857/4885CYP2C9 1218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.