Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3533920 | 0.89 | PIM1 (0.47) | ALDH1A1KMT2AMAPT | |
| SCHEMBL3518140 | 0.76 | FEN1 (0.44) | ALDH1A1POLBCYP3A4KMT2AHPGD | |
| SCHEMBL3517441 | 0.75 | PIK3CA (0.49) | CYP3A4USP2KMT2AKDM4E | |
| SCHEMBL3515039 | 0.75 | FABP3 (0.43) | ALDH1A1CYP2C19KDM4E | |
| SCHEMBL3518012 | 0.74 | SCN1A (0.44) | POLBKMT2ASCN5A | |
| SCHEMBL3516410 | 0.74 | ACVR1 (0.40) | SMN1; SMN2ALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL3514710 | 0.74 | P2RX7 (0.44) | SMN1; SMN2ALDH1A1POLBCYP3A4CYP2C19 | |
| SCHEMBL3518929 | 0.73 | FEN1 (0.47) | SMN1; SMN2ALDH1A1CYP1A2CYP2C19KMT2A | |
| SCHEMBL18335243 | 0.73 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1SCN9APOLBCYP1A2 | |
| SCHEMBL3515736 | 0.73 | ACP1 (0.47) | SMN1; SMN2ALDH1A1POLBMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | MERCK SHARP & DOHME CORP. | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | RNASEH1, RNASE1, RNASEL | SMN1; SMN2 1566/4885ALDH1A1 1486/4885SCN9A 1678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.