Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 3/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.35 |
| ▸ | CFD | P00746 | 2/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | KLK1 | P06870 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18314572 | 0.97 | IDH1 (0.39) | IDH1CYP2A6ADRB2FGFR1FGFR2 | |
| SCHEMBL3519281 | 0.96 | IDH1 (0.40) | IDH1FGFR1FGFR2FGFR3PRMT5 | |
| SCHEMBL3514555 | 0.93 | ADRB2 (0.39) | IDH1CYP2A6ADRB2PRMT5WDR77 | |
| SCHEMBL3514825 | 0.91 | IDH1 (0.41) | IDH1BACE1FEN1 | |
| SCHEMBL20278682 | 0.88 | IDH1 (0.41) | IDH1FGFR1BACE1FEN1MAPT | |
| SCHEMBL3519485 | 0.88 | IDH1 (0.40) | IDH1BACE1FEN1 | |
| SCHEMBL3514716 | 0.81 | PRMT5 (0.39) | IDH1FGFR1FGFR2FGFR3PRMT5 | |
| SCHEMBL3519733 | 0.81 | PRMT5 (0.40) | IDH1ADRB2PRMT5WDR77CFD | |
| SCHEMBL19509569 | 0.78 | CNR1 (0.30) | IDH1FGFR1FGFR2FGFR3 | |
| SCHEMBL19509157 | 0.78 | HDAC3 (0.39) | IDH1FEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | MERCK SHARP & DOHME CORP. | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | RNASEH1, RNASE1, RNASEL | IDH1 963/4885CYP2A6 1444/4885ADRB2 3530/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.