Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | CFD | P00746 | 5/20 | 0.39 |
| ▸ | VHL | P40337 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 2/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | WEE1 | P30291 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3514716 | 0.98 | PRMT5 (0.39) | PRMT5WDR77CFDVHLFEN1 | |
| SCHEMBL3515731 | 0.90 | VHL (0.39) | VHLLOXL2AKT1ELANE | |
| SCHEMBL3515077 | 0.89 | PRKCI (0.41) | VHLFEN1CHEK1IDH1PIK3CD | |
| SCHEMBL3519281 | 0.85 | IDH1 (0.40) | PRMT5WDR77CFDFEN1LOXL2 | |
| SCHEMBL3517754 | 0.82 | PIK3CD (0.52) | FEN1IDH1PIK3CDELANE | |
| SCHEMBL18314572 | 0.82 | IDH1 (0.39) | PRMT5WDR77CFDIDH1ADRB2 | |
| SCHEMBL3515937 | 0.82 | DRD2 (0.47) | MAPT | |
| SCHEMBL13435309 | 0.82 | CYP1A2 (0.41) | FEN1IDH1AKT1MAPT | |
| SCHEMBL4460861 | 0.82 | FEN1 (0.47) | FEN1 | |
| SCHEMBL3515013 | 0.81 | IDH1 (0.41) | PRMT5WDR77CFDFEN1IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | MERCK SHARP & DOHME CORP. | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | RNASEH1, RNASE1, RNASEL | PRMT5 2960/4885WDR77 1434/4885CFD 3645/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.