Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | NSD2 | O96028 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CDC25B | P30305 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3517502 | 0.94 | CD38 (0.48) | KDM4EALDH1A1TSHRSMN1; SMN2AURKA | |
| SCHEMBL15170510 | 0.85 | CYP3A4 (0.44) | CYP3A4NSD2KDM4EMEN1ALDH1A1 | |
| SCHEMBL2027531 | 0.80 | GBA1 (0.48) | CYP3A4NSD2KDM4EMEN1ALDH1A1 | |
| SCHEMBL15170500 | 0.79 | CD38 (0.44) | CYP3A4KDM4EALDH1A1MAPTTSHR | |
| SCHEMBL3520091 | 0.74 | CNR1 (0.42) | KDM4EALDH1A1RPS6KB1SCN8A | |
| SCHEMBL16749077 | 0.72 | FEN1 (0.31) | — | |
| SCHEMBL18136095 | 0.72 | FEN1 (0.47) | KDM4EMEN1ALDH1A1KMT2ACYP2C9 | |
| SCHEMBL3517491 | 0.72 | KDM4E (0.51) | KDM4EMEN1MAPTMAPK1KMT2A | |
| SCHEMBL3518140 | 0.71 | FEN1 (0.44) | CYP3A4KDM4EMEN1ALDH1A1TP53 | |
| SCHEMBL3517392 | 0.70 | ROCK2 (0.52) | KDM4ESCN1ASCN8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10980754-B2 | Anti-fungal compounds | SAINT LOUIS UNIVERSITY (US) | 2021-04-20 | — | — | US | disclosed |
| US-10463664-B2 | Inhibitors of HSV nucleotidyl transferases and uses therefor | SAINT LOUIS UNIVERSITY (US) | 2019-11-05 | — | — | US | disclosed |
| US-20190099385-A1 | ANTI-FUNGAL COMPOUNDS | SAINT LOUIS UNIVERSITY (US) | 2019-04-04 | — | — | US | disclosed |
| WO-2017184752-A1 | ANTI-FUNGAL COMPOUNDS | SAINT LOUIS UNIVERSITY (US) | 2017-10-26 | — | — | WO | disclosed |
| US-20160296521-A1 | INHIBITORS OF HSV NUCLEOTIDYL TRANSFERASES AND USES THEREFOR | SAINT LOUIS UNIVERSITY (US) | 2016-10-13 | — | — | US | disclosed |
| US-20160296521-A1 | INHIBITORS OF HSV NUCLEOTIDYL TRANSFERASES AND USES THEREFOR | SAINT LOUIS UNIVERSITY (US) | 2016-10-13 | — | — | US | disclosed |
| WO-2015077774-A1 | INHIBITORS OF HSV NUCLEOTIDYL TRANSFERASES AND USES THEREFOR | SAINT LOUIS UNIVERSITY (US) | 2015-05-28 | — | — | WO | disclosed |
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | MERCK SHARP & DOHME CORP. | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | RNASEH1, RNASE1, RNASEL | CYP3A4 857/4885NSD2 1187/4885KDM4E 2380/4885 |
| US-20190099385-A1 | ANTI-FUNGAL COMPOUNDS | ERG28, NANS, DPM1 | CYP3A4 1898/4885NSD2 1244/4885KDM4E 2966/4885 |
| US-20160296521-A1 | INHIBITORS OF HSV NUCLEOTIDYL TRANSFERASES AND USES THEREFOR | TYMP, TYMS, NAMPT | CYP3A4 1733/4885NSD2 2102/4885KDM4E 1902/4885 |
| US-10980754-B2 | Anti-fungal compounds | ERG28, NANS, DPM1 | CYP3A4 1898/4885NSD2 1244/4885KDM4E 2966/4885 |
| US-10463664-B2 | Inhibitors of HSV nucleotidyl transferases and uses therefor | TYMP, TYMS, NAMPT | CYP3A4 1733/4885NSD2 2102/4885KDM4E 1902/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.