Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PPIA | P62937 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3515840 | 0.83 | SMN1; SMN2 (0.40) | MEN1KMT2APPIASMN1; SMN2MAPT | |
| SCHEMBL3515597 | 0.81 | ALDH1A1 (0.42) | MEN1KMT2ASMN1; SMN2MAPTTP53 | |
| SCHEMBL3515379 | 0.80 | KDM4E (0.45) | MEN1KMT2ASMN1; SMN2MAPTTP53 | |
| SCHEMBL3514631 | 0.78 | ALDH1A1 (0.41) | MEN1KMT2ASMN1; SMN2MAPTTP53 | |
| SCHEMBL3517696 | 0.77 | ALDH1A1 (0.40) | BRD4MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL3519112 | 0.76 | MEN1 (0.54) | MEN1KMT2AATMTP53ALOX15 | |
| SCHEMBL3519104 | 0.75 | ALDH1A1 (0.39) | MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL3519074 | 0.74 | PIK3CD (0.44) | MEN1KMT2ASMN1; SMN2MAPTTP53 | |
| SCHEMBL3514876 | 0.73 | CNR2 (0.44) | MEN1KMT2ASMN1; SMN2MAPTTP53 | |
| SCHEMBL16238692 | 0.72 | CNR2 (0.46) | MEN1KMT2AMAPTTP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | MERCK SHARP & DOHME CORP. | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | RNASEH1, RNASE1, RNASEL | BRD4 2682/4885MEN1 3126/4885KMT2A 2764/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.