Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.55 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.55 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.55 |
| ▸ | KMO | O15229 | 1/20 | 0.55 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.54 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.54 |
| ▸ | CFTR | P13569 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.47 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.47 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.47 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3514338 | 0.87 | MKNK1 (0.60) | CYP11B1CYP11B2CYP19A1SLC2A1MKNK1 | |
| SCHEMBL31209946 | 0.86 | KMO (0.64) | CYP11B1CYP11B2SLC2A1KMOMKNK1 | |
| SCHEMBL3517388 | 0.86 | KMO (0.64) | CYP11B1CYP11B2SLC2A1KMOMKNK1 | |
| SCHEMBL3515844 | 0.85 | NR4A2 (0.57) | CYP11B1CYP11B2CYP19A1SLC2A1MKNK1 | |
| SCHEMBL20118979 | 0.83 | CYP46A1 (0.56) | CYP11B1CYP11B2CYP19A1SLC2A1MKNK1 | |
| SCHEMBL3515912 | 0.82 | CFTR (0.53) | CYP11B1CYP11B2CYP19A1SLC2A1MKNK1 | |
| SCHEMBL20178609 | 0.81 | CFTR (0.52) | CYP11B1CYP11B2CYP19A1SLC2A1MKNK1 | |
| SCHEMBL20173748 | 0.80 | NR4A2 (0.51) | CYP11B1CYP11B2CYP19A1SLC2A1MKNK1 | |
| SCHEMBL13435236 | 0.80 | KMT2A (0.61) | CYP11B1CYP11B2CYP19A1SLC2A1CFTR | |
| SCHEMBL29644805 | 0.80 | KMT2A (0.61) | CYP11B1CYP11B2CYP19A1SLC2A1CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | MERCK SHARP & DOHME CORP. | 2010-03-04 | — | — | US | disclosed |
| EP-2044068-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | Merck & Co., Inc. (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008010964-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | MERCK & CO., INC. (US) | 2008-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | RNASEH1, RNASE1, RNASEL | CYP11B1 2412/4885CYP11B2 3231/4885CYP19A1 524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.