Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ACACB | O00763 | 3/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3517034 | 0.86 | KDM4E (0.47) | KDM4ERECQLALDH1A1RAB9ANPC1 | |
| SCHEMBL3517790 | 0.85 | MAPT (0.48) | KDM4ERECQLALDH1A1RAB9ANPC1 | |
| SCHEMBL3518509 | 0.80 | KDM4E (0.50) | KDM4ERECQLALDH1A1LMNAGAA | |
| SCHEMBL3516288 | 0.80 | P2RY12 (0.49) | KDM4EALDH1A1RAB9ANPC1LMNA | |
| SCHEMBL3517794 | 0.80 | KDM4E (0.44) | KDM4ERECQLALDH1A1RAB9ALMNA | |
| SCHEMBL3517896 | 0.78 | KDM4E (0.42) | KDM4ERECQLALDH1A1LMNAGAA | |
| SCHEMBL3517521 | 0.78 | ALDH1A1 (0.44) | KDM4ERECQLALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL13435287 | 0.78 | ROCK2 (0.50) | LMNATP53SMN1; SMN2KMT2A | |
| SCHEMBL3519481 | 0.77 | KDM4E (0.51) | KDM4ERECQLALDH1A1RAB9ANPC1 | |
| SCHEMBL13435288 | 0.77 | P2RY12 (0.52) | KDM4EALDH1A1NPC1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | MERCK SHARP & DOHME CORP. | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | RNASEH1, RNASE1, RNASEL | KDM4E 2380/4885ACACB 3433/4885RECQL 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.