Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 7/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | SCN1A | P35498 | 6/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 6/20 | 0.42 |
| ▸ | SCN8A | Q9UQD0 | 6/20 | 0.42 |
| ▸ | AKT1 | P31749 | 5/20 | 0.39 |
| ▸ | INCENP | Q9NQS7 | 5/20 | 0.39 |
| ▸ | PDE8B | O95263 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3518012 | 0.90 | SCN1A (0.44) | RPS6KB1AURKBAURKASCN1ASCN5A | |
| SCHEMBL3514910 | 0.78 | KDM4E (0.43) | TP53KDM4EHTTSMN1; SMN2 | |
| SCHEMBL3514723 | 0.78 | KDM4E (0.43) | TP53KDM4EHTTSMN1; SMN2 | |
| SCHEMBL3516717 | 0.78 | KDM4E (0.43) | TP53KDM4EHTTSMN1; SMN2 | |
| SCHEMBL3533920 | 0.73 | PIM1 (0.47) | LMNANPSR1L3MBTL1 | |
| SCHEMBL15060290 | 0.73 | RPS6KB1 (0.68) | RPS6KB1AURKBAURKAAKT1INCENP | |
| SCHEMBL3518140 | 0.71 | FEN1 (0.44) | AURKATP53ALOX15KDM4EGLA | |
| SCHEMBL3514710 | 0.71 | P2RX7 (0.44) | KDM4ELMNACYP2C19RAB9ASMN1; SMN2 | |
| SCHEMBL3516223 | 0.71 | BACE1 (0.49) | RPS6KB1TP53KDM4ENPC1HTT | |
| SCHEMBL18136095 | 0.70 | FEN1 (0.47) | KDM4ECYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | MERCK SHARP & DOHME CORP. | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | RNASEH1, RNASE1, RNASEL | RPS6KB1 510/4885AURKB 2440/4885AURKA 2738/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.