Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.46 |
| ▸ | ELANE | P08246 | 4/20 | 0.44 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | FEN1 | P39748 | 2/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | FASN | P49327 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.36 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.36 |
| ▸ | USP14 | P54578 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13435249 | 0.76 | FEN1 (0.46) | FEN1KDM4E | |
| SCHEMBL3516363 | 0.72 | SLC11A2 (0.47) | KMT2AMEN1SLC11A2ELANEKDM4E | |
| SCHEMBL13435251 | 0.71 | FEN1 (0.53) | FEN1KDM4E | |
| SCHEMBL13461600 | 0.69 | FEN1 (0.47) | KMT2AMEN1FEN1KDM4E | |
| SCHEMBL2022418 | 0.68 | ABCG2 (0.51) | KMT2AMEN1ATMELANEPTGDR2 | |
| SCHEMBL16250051 | 0.68 | FEN1 (0.49) | FEN1KDM4E | |
| SCHEMBL3518030 | 0.68 | FEN1 (0.49) | KMT2AMEN1FEN1KDM4E | |
| SCHEMBL19435524 | 0.68 | IL1B (0.45) | KMT2AMEN1ATMELANEKDM4E | |
| SCHEMBL8801781 | 0.68 | KMT2A (0.54) | KMT2AMEN1PDE4AFEN1KDM4E | |
| SCHEMBL3514691 | 0.67 | FEN1 (0.58) | PDE4AFEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | MERCK SHARP & DOHME CORP. | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056516-A1 | 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS | RNASEH1, RNASE1, RNASEL | KMT2A 2764/4885MEN1 3126/4885ATM 3402/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.