Tolnaftate

Tolnaftate

SCHEMBL3520

Cc1cccc(N(C)C(=S)Oc2ccc3ccccc3c2)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 6/20 1.00
MAPT P10636 4/20 1.00
TDP1 Q9NUW8 3/20 1.00
NR1I2 O75469 2/20 1.00
CYP1A2 P05177 2/20 1.00
CYP3A4 P08684 1/20 1.00
CYP2C9 P11712 1/20 1.00
MAPK1 P28482 1/20 1.00
CYP2C19 P33261 1/20 1.00
HTR2B P41595 1/20 1.00
CYP51A1 Q16850 1/20 1.00
HSD17B1 P14061 3/20 0.45
HSD17B2 P37059 3/20 0.45
SIGMAR1 Q99720 2/20 0.43
SMN1; SMN2 Q16637 3/20 0.42
HTT P42858 1/20 0.42
KMT2A Q03164 2/20 0.41
ESR1 P03372 1/20 0.41
CYP2A6 P11509 2/20 0.40
MAOA P21397 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tolnaftate SCHEMBL8160019 1.00 LMNA (1.00) LMNAMAPTTDP1NR1I2CYP1A2
Tolnaftate SCHEMBL30382951 1.00 LMNA (1.00) LMNAMAPTTDP1NR1I2CYP1A2
Tolnaftate SCHEMBL29484221 1.00 LMNA (1.00) LMNAMAPTTDP1NR1I2CYP1A2
Tolnaftate SCHEMBL10897084 0.99 LMNA (0.97) LMNAMAPTTDP1NR1I2CYP1A2
Tolnaftate SCHEMBL22227756 0.99 LMNA (0.97) LMNAMAPTTDP1NR1I2CYP1A2
Tolnaftate SCHEMBL28341077 0.99 LMNA (0.97) LMNAMAPTTDP1NR1I2CYP1A2
Tolnaftate SCHEMBL8985002 0.95 LMNA (0.90) LMNAMAPTTDP1NR1I2CYP1A2
Tolnaftate SCHEMBL8609283 0.94 LMNA (0.88) LMNAMAPTTDP1NR1I2CYP1A2
Tolnaftate SCHEMBL15568032 0.94 MAPT (0.88) LMNAMAPTTDP1NR1I2CYP1A2
Tolnaftate SCHEMBL893162 0.94 LMNA (0.88) LMNAMAPTTDP1NR1I2CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 20537 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4255391-B1 LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION METRIOPHARM AG (CH) 2026-05-06 EP claimed
US-12616675-B1 Antifungal liquid and antifungal gel The Tetra Corporation (US) 2026-05-05 US claimed
EP-4719384-A2 COMPOUNDS WITH ANTIFUNGAL PROPERTIES Trustees of Dartmouth College (US) 2026-04-08 EP claimed
US-20260027140-A1 COMPOSITIONS AND METHODS FOR TREATING AND AMELIORATING RESPIRATORY CONDITIONS AND INFLAMMATION OF MUCOSA ATOPIC MEDICAL INC (US) 2026-01-29 US claimed
EP-4676500-A2 MICROBIAL CONSORTIA Kanvas Biosciences, Inc (US) 2026-01-14 EP claimed
US-20260007753-A1 DERMAL SKIN PROTECTANT AND CARRIER INSPIRED MAT STRATEGIES LLC (US) 2026-01-08 US claimed
EP-4659014-A1 EMULSION-BASED THICK-FILM ANTIFOULING COATING FOR HIGHLY SENSITIVE ELECTROCHEMICAL SENSING President And Fellows Of Harvard College (US) 2025-12-10 EP claimed
EP-4646740-A1 METHOD FOR PRODUCING AN OPTOELECTRONIC COMPONENT, AND OPTOELECTRONIC COMPONENT AMS-OSRAM INTERNATIONAL GMBH (DE) 2025-11-12 EP claimed
US-20250332120-A1 COMPOSITION FOR EXTERNAL PREPARATION KAO CORPORATION (JP) 2025-10-30 US claimed
US-12427109-B2 Natural origin stabilizer for oil in water emulsions FUNDACIÓN CIDETEC (ES) 2025-09-30 US claimed
US-4723950-A SUSTAINED RELEASE OF MICROBIOCIDES BY SWELLABLE POLYMER C. R. BARD, INC. (US) 1988-02-09 US claimed
WO-1987005806-A1 DUAL PHASE SOLVENT CARRIER SYSTEM UNIVERSITY OF SOUTHERN CALIFORNIA (US) 1987-10-08 WO claimed
EP-0184629-A2 Urine drainage bag outlet with barrier against microbial infection C.R. BARD, INC. (US) 1986-06-18 EP claimed
US-RE32145-E FUNGISTAT HERCULES INCORPORATED (US) 1986-05-13 US claimed
EP-0126684-A2 Drug delivery system utilizing thermosetting gels MERCK & CO. INC. (US) 1984-11-28 EP claimed
EP-0125759-A2 Topical composition of antibiotics for application to the mucosa WARNER LAMBERT HOLLAND B.V. (NL) 1984-11-21 EP claimed
US-4474753-A POLYETHERAMINE MERCK & CO., INC. (US) 1984-10-02 US claimed
WO-1983002894-A1 ANTI-VIRAL TREATMENT METHOD BEAUMONT, CAMERON, ALLAN 1983-09-01 WO claimed
EP-0063773-A1 Orally active tolciclate and tolnaftate ADRIA LABORATORIES, INC. (US) 1982-11-03 EP claimed
US-4348407-A Orally active tolciclate and tolnaftate ADRIA LABORATORIES, INC. (US) 1982-09-07 US claimed