Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Tolnaftate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.88 |
| ▸ | MAPT | P10636 | 4/20 | 0.88 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.88 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.88 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.88 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.88 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.88 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.88 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.88 |
| ▸ | HTR2B | P41595 | 1/20 | 0.88 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.88 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tolnaftate SCHEMBL29484221 | 0.94 | LMNA (1.00) | LMNAMAPTTDP1NR1I2CYP1A2 | |
| Tolnaftate SCHEMBL30382951 | 0.94 | LMNA (1.00) | LMNAMAPTTDP1NR1I2CYP1A2 | |
| Tolnaftate SCHEMBL3520 | 0.94 | LMNA (1.00) | LMNAMAPTTDP1NR1I2CYP1A2 | |
| Tolnaftate SCHEMBL8160019 | 0.94 | LMNA (1.00) | LMNAMAPTTDP1NR1I2CYP1A2 | |
| Tolnaftate SCHEMBL28341077 | 0.92 | LMNA (0.97) | LMNAMAPTTDP1NR1I2CYP1A2 | |
| Tolnaftate SCHEMBL22227756 | 0.92 | LMNA (0.97) | LMNAMAPTTDP1NR1I2CYP1A2 | |
| Tolnaftate SCHEMBL10897084 | 0.92 | LMNA (0.97) | LMNAMAPTTDP1NR1I2CYP1A2 | |
| Tolnaftate SCHEMBL3216288 | 0.89 | LMNA (0.86) | LMNAMAPTTDP1NR1I2CYP1A2 | |
| Tolnaftate SCHEMBL29091994 | 0.89 | LMNA (0.86) | LMNAMAPTTDP1NR1I2CYP1A2 | |
| Tolnaftate SCHEMBL8985002 | 0.89 | LMNA (0.90) | LMNAMAPTTDP1NR1I2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403903-B1 | RADIATION-ABSORBING MATERIAL | CHEM FAB BUDENHEIM KG (DE) | 2013-12-11 | — | — | EP | claimed |
| US-20120082834-A1 | RADIATION-ABSORBING MATERIAL | CHEMISCHE FABRIK BUDENHEIM KG (DE) | 2012-04-05 | — | — | US | claimed |
| US-10633538-B2 | Plastics moulding composition and use thereof | EMS-PATENT AG (CH) | 2020-04-28 | — | — | US | disclosed |
| US-10440832-B2 | Plastic molding compound and use thereof | EMS-PATENT AG (CH) | 2019-10-08 | — | — | US | disclosed |
| US-10023465-B2 | Doped copper-II-hydroxide phosphate, method for producing same and use thereof | CHEMISCHE FABRIK BUDENHEIM KG (DE) | 2018-07-17 | — | — | US | disclosed |
| US-20160295705-A1 | PLASTIC MOLDING COMPOUND AND USE THEREOF | EMS-PATENT AG (CH) | 2016-10-06 | — | — | US | disclosed |
| US-20160280544-A1 | DOPED COPPER-II-HYDROXIDE PHOSPHATE, METHOD FOR PRODUCING SAME AND USE THEREOF | CHEMISCHE FABRIK BUDENHEIM KG (DE) | 2016-09-29 | — | — | US | disclosed |
| US-20150175803-A1 | PLASTICS MOULDING COMPOSITION AND USE THEREOF | EMS-PATENT AG (CH) | 2015-06-25 | — | — | US | disclosed |
| US-8293147-B2 | Laser-writable polymer material | CHEMISCHE FABRIK BUDENHEIM KG (DE) | 2012-10-23 | — | — | US | disclosed |
| US-20120082834-A1 | RADIATION-ABSORBING MATERIAL | CHEMISCHE FABRIK BUDENHEIM KG (DE) | 2012-04-05 | — | — | US | disclosed |
| US-20100140571-A1 | LASER-WRITABLE POLYMER MATERIAL | CHEMISCHE FABRIK BUDENHEIM KG (DE) | 2010-06-10 | — | — | US | disclosed |