Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Tolnaftate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.90 |
| ▸ | MAPT | P10636 | 3/20 | 0.90 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.90 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.90 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.90 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.90 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.90 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.90 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.90 |
| ▸ | HTR2B | P41595 | 1/20 | 0.90 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.90 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tolnaftate SCHEMBL30382951 | 0.95 | LMNA (1.00) | LMNAMAPTTDP1NR1I2CYP1A2 | |
| Tolnaftate SCHEMBL8160019 | 0.95 | LMNA (1.00) | LMNAMAPTTDP1NR1I2CYP1A2 | |
| Tolnaftate SCHEMBL3520 | 0.95 | LMNA (1.00) | LMNAMAPTTDP1NR1I2CYP1A2 | |
| Tolnaftate SCHEMBL29484221 | 0.95 | LMNA (1.00) | LMNAMAPTTDP1NR1I2CYP1A2 | |
| Tolnaftate SCHEMBL10897084 | 0.94 | LMNA (0.97) | LMNAMAPTTDP1NR1I2CYP1A2 | |
| Tolnaftate SCHEMBL22227756 | 0.94 | LMNA (0.97) | LMNAMAPTTDP1NR1I2CYP1A2 | |
| Tolnaftate SCHEMBL28341077 | 0.94 | LMNA (0.97) | LMNAMAPTTDP1NR1I2CYP1A2 | |
| Tolnaftate SCHEMBL893162 | 0.89 | LMNA (0.88) | LMNAMAPTTDP1NR1I2CYP1A2 | |
| Tolnaftate SCHEMBL8609283 | 0.89 | LMNA (0.88) | LMNAMAPTTDP1NR1I2CYP1A2 | |
| Tolnaftate SCHEMBL15568032 | 0.89 | MAPT (0.88) | LMNAMAPTTDP1NR1I2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5519059-A | OF ISOPROPYL ALCOHOL, ISOPROPYL MYRISTATE, POLYOXYETHYLENE GLYCOL AND TOLNAFTATE | SAWAYA ASSAD S (US) | 1996-05-21 | — | — | US | disclosed |