Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 4/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.32 |
| ▸ | NT5E | P21589 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CHKA | P35790 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.31 |
| ▸ | WNT1 | P04628 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL35211471 | 0.79 | TRPA1 (0.41) | TRPA1PIM1IDO1LRRK2TRPV4 | |
| SCHEMBL21055204 | 0.73 | GABRP (0.43) | TRPA1PIM1LRRK2GSK3AGSK3B | |
| SCHEMBL31317680 | 0.73 | UHRF1 (0.36) | PIM1LRRK2GSK3AGSK3BDYRK1A | |
| SCHEMBL12479452 | 0.73 | UHRF1 (0.36) | PIM1LRRK2GSK3AGSK3BDYRK1A | |
| SCHEMBL25241733 | 0.70 | MAP2K4 (0.56) | TRPA1KDM4EGSK3B | |
| SCHEMBL30481232 | 0.70 | MAP2K4 (0.56) | TRPA1KDM4EGSK3B | |
| SCHEMBL30481233 | 0.67 | TRPA1 (0.55) | TRPA1GSK3B | |
| SCHEMBL25279396 | 0.67 | TRPA1 (0.55) | TRPA1GSK3B | |
| SCHEMBL29361220 | 0.66 | PDPK1 (0.38) | TRPA1GSK3BDYRK1A | |
| SCHEMBL12479638 | 0.66 | METAP2 (0.49) | TRPA1PIM1KDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260125375-A1 | SUBSTITUTED 1H-PYRAZOLO-PYRIDINE AND -PYRIMIDINE COMPOUNDS | PFIZER INC. (US) | 2026-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260125375-A1 | SUBSTITUTED 1H-PYRAZOLO-PYRIDINE AND -PYRIMIDINE COMPOUNDS | CCR1, CCR6, CCRL2 | TRPA1 3698/4885PIM1 1535/4885IDO1 278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.