Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 4/20 | 0.39 |
| ▸ | DRD4 | P21917 | 4/20 | 0.39 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | RXRG | P48443 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3521856 | 0.84 | DRD2 (0.41) | PGRDRD2DRD4HSD17B3RXRA | |
| SCHEMBL3518811 | 0.81 | PGR (0.41) | PGRDRD2DRD4MAPTTDP1 | |
| SCHEMBL3522109 | 0.80 | BCHE (0.41) | PGRMAPTLMNAMEN1ALDH1A1 | |
| SCHEMBL3522498 | 0.69 | DRD2 (0.49) | PGRDRD2DRD4HSD17B3MAPT | |
| SCHEMBL3522804 | 0.65 | PGR (0.42) | PGRDRD2DRD4MAPTTDP1 | |
| SCHEMBL3520212 | 0.65 | TP53 (0.46) | MAPTLMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL1921628 | 0.61 | KDM4E (0.59) | DRD2DRD4MAPTLMNACNR1 | |
| SCHEMBL3785566 | 0.61 | ITGA1 (0.54) | DRD2DRD4MAPTLMNACNR1 | |
| SCHEMBL5022723 | 0.59 | PGR (0.64) | PGRDRD2DRD4HSD17B3NOTUM | |
| SCHEMBL3522292 | 0.59 | PGR (0.64) | PGRDRD2DRD4HSD17B3NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7737136-B2 | Non-steroidal progesterone receptor modulators | N.V. ORGANON (NL) | 2010-06-15 | — | — | US | disclosed |
| EP-1495030-B1 | NON-STEROIDAL PROGESTERONE RECEPTOR MODULATORS | ORGANON NV (NL) | 2008-08-13 | — | — | EP | disclosed |
| US-20050171087-A1 | Non-steroidal progesterone receptor modulators | MERCK SHARP & DOHME B.V. (NL) | 2005-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050171087-A1 | Non-steroidal progesterone receptor modulators | PGR, PGRMC1, PGRMC2 | PGR 1/4885DRD2 2299/4885DRD4 2339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.