Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.49 |
| ▸ | DRD4 | P21917 | 6/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | ITGA1 | P56199 | 1/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3522208 | 0.75 | CYP2D6 (0.40) | DRD2DRD4ACHEHTR1AADRA2A | |
| SCHEMBL3521538 | 0.75 | DRD2 (0.49) | DRD2DRD4HTR1AADRA2AADRA2C | |
| SCHEMBL3522522 | 0.69 | PGR (0.40) | DRD2DRD4ITGA1ALDH1A1KDM4E | |
| SCHEMBL3521856 | 0.68 | DRD2 (0.41) | DRD2DRD4ALDH1A1KDM4ELMNA | |
| SCHEMBL3785566 | 0.68 | ITGA1 (0.54) | DRD2DRD4ACHEITGA1ADRA2A | |
| SCHEMBL1921628 | 0.68 | KDM4E (0.59) | DRD2DRD4ITGA1ADRA2AHTR2C | |
| SCHEMBL1115813 | 0.66 | ACHE (0.38) | DRD2DRD4ACHEADRA1AALDH1A1 | |
| SCHEMBL13934606 | 0.65 | DRD2 (0.75) | DRD2DRD4HTR3EHTR3BHTR1A | |
| SCHEMBL6899110 | 0.62 | MAOA (0.67) | DRD2DRD4ITGA1CYP1A2ALDH1A1 | |
| SCHEMBL10694841 | 0.62 | MAOA (0.67) | DRD2DRD4ITGA1CYP1A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7737136-B2 | Non-steroidal progesterone receptor modulators | N.V. ORGANON (NL) | 2010-06-15 | — | — | US | disclosed |
| EP-1495030-B1 | NON-STEROIDAL PROGESTERONE RECEPTOR MODULATORS | ORGANON NV (NL) | 2008-08-13 | — | — | EP | disclosed |
| US-20050171087-A1 | Non-steroidal progesterone receptor modulators | MERCK SHARP & DOHME B.V. (NL) | 2005-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050171087-A1 | Non-steroidal progesterone receptor modulators | PGR, PGRMC1, PGRMC2 | DRD2 2299/4885DRD4 2339/4885ACHE 4658/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.