SCHEMBL3523036

SCHEMBL3523036

COc1cc2c(c(OC)c1)C(C)=CC(C)(C)N2

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 7/20 0.60
▸ KDM4E B2RXH2 7/20 0.60
▸ MAPT P10636 4/20 0.60
▸ MEN1 O00255 4/20 0.60
▸ KMT2A Q03164 4/20 0.60
▸ HPGD P15428 5/20 0.46
▸ HSD17B10 Q99714 4/20 0.46
▸ LMNA P02545 2/20 0.46
▸ PGR P06401 7/20 0.45
▸ TDP1 Q9NUW8 3/20 0.43
▸ CYP3A4 P08684 2/20 0.43
▸ CYP1A2 P05177 1/20 0.43
▸ CYP2D6 P10635 1/20 0.43
▸ CYP2C9 P11712 1/20 0.43
▸ ALOX15 P16050 1/20 0.43
▸ ALOX12 P18054 1/20 0.43
▸ CYP2C19 P33261 1/20 0.43
▸ HIF1A Q16665 1/20 0.43
▸ HTR6 P50406 1/20 0.42
▸ NR3C1 P04150 6/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9709027 0.79 ALDH1A1 (0.48) ALDH1A1KDM4EMAPTMEN1KMT2A
SCHEMBL1394706 0.77 ALDH1A1 (0.97) ALDH1A1KDM4EMAPTMEN1KMT2A
SCHEMBL6470321 0.77 ALDH1A1 (0.53) ALDH1A1KDM4EMAPTMEN1KMT2A
SCHEMBL29430126 0.77 ALDH1A1 (0.97) ALDH1A1KDM4EMAPTMEN1KMT2A
Bromide SCHEMBL7802438 0.75 ALDH1A1 (0.94) ALDH1A1KDM4EMAPTMEN1KMT2A
SCHEMBL1322296 0.73 ALDH1A1 (0.74) ALDH1A1KDM4EMAPTMEN1KMT2A
SCHEMBL7073387 0.71 KDM4E (0.71) ALDH1A1KDM4EMAPTMEN1KMT2A
SCHEMBL9760350 0.70 ALDH1A1 (0.53) ALDH1A1KDM4EMAPTMEN1KMT2A
SCHEMBL30973139 0.69 KDM4E (0.83) ALDH1A1KDM4EMAPTMEN1KMT2A
Difucol Hexamethyl Ether SCHEMBL505203 0.69 CYP1A2 (0.60) ALDH1A1MAPTLMNACYP3A4CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4008790-B1 MONOAZO DYES WITH CYCLIC AMINE AS FLUORESCENCE QUENCHERS ENZO BIOCHEM INC (US) 2024-07-17 — — EP disclosed
EP-4008790-B1 MONOAZO DYES WITH CYCLIC AMINE AS FLUORESCENCE QUENCHERS ENZO BIOCHEM INC (US) 2024-07-17 — — EP disclosed
EP-4008790-A1 MONOAZO DYES WITH CYCLIC AMINE AS FLUORESCENCE QUENCHERS Enzo Biochem, Inc. (US) 2022-06-08 — — EP disclosed
EP-4008790-A1 MONOAZO DYES WITH CYCLIC AMINE AS FLUORESCENCE QUENCHERS Enzo Biochem, Inc. (US) 2022-06-08 — — EP disclosed
EP-3277832-B1 MONOAZO DYES WITH CYCLIC AMINE AS FLUORESCENCE QUENCHERS ENZO BIOCHEM INC (US) 2021-10-06 — — EP disclosed
EP-3277832-B1 MONOAZO DYES WITH CYCLIC AMINE AS FLUORESCENCE QUENCHERS ENZO BIOCHEM INC (US) 2021-10-06 — — EP disclosed
US-20210079225-A1 MONOAZO DYES WITH CYCLIC AMINE AS FLUORESCENCE QUENCHERS ENZO BIOCHEM, INC. (US) 2021-03-18 — — US disclosed
US-20210079225-A1 MONOAZO DYES WITH CYCLIC AMINE AS FLUORESCENCE QUENCHERS ENZO BIOCHEM, INC. (US) 2021-03-18 — — US disclosed
US-10865309-B2 Monoazo dyes with cyclic amine as fluorescence quenchers ENZO BIOCHEM, INC. (US) 2020-12-15 — — US disclosed
US-10865309-B2 Monoazo dyes with cyclic amine as fluorescence quenchers ENZO BIOCHEM, INC. (US) 2020-12-15 — — US disclosed
US-20170369954-A1 MONOAZO DYES WITH CYCLIC AMINE AS FLUORESCENCE QUENCHERS ENZO BIOCHEM, INC. (US) 2017-12-28 — — US disclosed
US-20170369954-A1 MONOAZO DYES WITH CYCLIC AMINE AS FLUORESCENCE QUENCHERS ENZO BIOCHEM, INC. (US) 2017-12-28 — — US disclosed
WO-2016160051-A1 MONOAZO DYES WITH CYCLIC AMINE AS FLUORESCENCE QUENCHERS ENZO BIOCHEM, INC. (US) 2016-10-06 — — WO disclosed
WO-2016160051-A1 MONOAZO DYES WITH CYCLIC AMINE AS FLUORESCENCE QUENCHERS ENZO BIOCHEM, INC. (US) 2016-10-06 — — WO disclosed
US-20160289779-A1 MONOAZO DYES WITH CYCLIC AMINE AS FLUORESCENCE QUENCHERS ENZO BIOCHEM, INC. (US) 2016-10-06 — — US disclosed
US-20160289779-A1 MONOAZO DYES WITH CYCLIC AMINE AS FLUORESCENCE QUENCHERS ENZO BIOCHEM, INC. (US) 2016-10-06 — — US disclosed
US-20160289779-A1 MONOAZO DYES WITH CYCLIC AMINE AS FLUORESCENCE QUENCHERS ENZO BIOCHEM, INC. (US) 2016-10-06 — — US disclosed
US-7858794-B2 Tetrahydroquinoline derivatives N.V. ORGANON (NL) 2010-12-28 — — US disclosed
EP-1578726-B1 TETRAHYDROQUINOLINE DERIVATIVES ORGANON NV (NL) 2009-02-25 — — EP disclosed
US-20060142334-A1 Tetrahydroquinoline derivatives MERCK SHARP & DOHME B.V. (NL) 2006-06-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060142334-A1 Tetrahydroquinoline derivatives GNRHR, KCNH3, HCAR3 ALDH1A1 1133/4885KDM4E 394/4885MAPT 4864/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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