Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | AGXT | P21549 | 2/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1176609 | 0.87 | ALDH1A1 (0.45) | TDP1LTA4HALDH1A1HTTCYP3A4 | |
| SCHEMBL3678427 | 0.85 | CYP1A2 (0.52) | IDO1CYP1A2CYP2A6TAAR1TDP1 | |
| SCHEMBL1149394 | 0.84 | IDO1 (0.58) | IDO1SRD5A2CYP1A2CYP2A6TAAR1 | |
| SCHEMBL11410252 | 0.84 | IDO1 (0.58) | IDO1SRD5A2CYP1A2CYP2A6TAAR1 | |
| SCHEMBL320687 | 0.84 | CALM1 (0.44) | TDP1ALDH1A1CYP3A4TSHRMAPK1 | |
| SCHEMBL28137856 | 0.81 | IDH1 (0.36) | TDP1ACHEALDH1A1CYP3A4TSHR | |
| SCHEMBL28715201 | 0.81 | IGF1R (0.52) | IDO1CYP1A2CYP2A6TAAR1ACHE | |
| SCHEMBL12505677 | 0.81 | CYP1A2 (0.48) | IDO1CYP1A2CYP2A6TAAR1TDP1 | |
| SCHEMBL27767683 | 0.80 | CYP2A6 (0.44) | CYP2A6TAAR1TDP1ALDH1A1CYP3A4 | |
| SCHEMBL4573326 | 0.79 | CHRM2 (0.53) | IDO1ALDH1A1HTTCYP3A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086960-B1 | NOVEL INHIBITORS OF GLUTAMINYL CYCLASE | PROBIODRUG AG (DE) | 2014-03-05 | — | — | EP | disclosed |
| US-7741354-B2 | Inhibitors of glutaminyl cyclase | PROBIODRUG AG (DE) | 2010-06-22 | — | — | US | disclosed |
| EP-2086960-A1 | NOVEL INHIBITORS OF GLUTAMINYL CYCLASE | Probiodrug AG (DE) | 2009-08-12 | — | — | EP | disclosed |
| US-20080207715-A1 | Novel Inhibitors of Glutaminyl Cyclase | PROBIODRUG AG (DE) | 2008-08-28 | — | — | US | disclosed |
| WO-2008055950-A1 | NOVEL INHIBITORS OF GLUTAMINYL CYCLASE | PROBIODRUG AG (DE) | 2008-05-15 | — | — | WO | disclosed |
| US-7217493-B2 | acid-decomposable group-containing polysiloxane or polysilsesquioxane and a specific amount of an acid generator that generates a sulfonic acid, and an organic base; high sensitivity, high resolution and good line edge roughness | FUJIFILM CORPORATION (JP) | 2007-05-15 | — | — | US | disclosed |
| US-6858731-B1 | Process for the preparation of pure stereoisomers of tetrahydrofolic acid esters salts and tetrahydrofolic acid by fractionated crystallization of tetrahydrofolic acid esters salts | EPROVA AG (CH) | 2005-02-22 | — | — | US | disclosed |
| US-20040229161-A1 | Positive resist composition | FUJI PHOTO FILM CO., LTD. | 2004-11-18 | — | — | US | disclosed |
| US-20040077019-A1 | Tagging compounds and process for use in aida libraries | GSTACH HUBERT (AT) | 2004-04-22 | — | — | US | disclosed |
| EP-1332135-A1 | TAGGING COMPOUNDS AND PROCESS FOR USE IN AIDA LIBRARIES | Novartis AG (CH) | 2003-08-06 | — | — | EP | disclosed |
| WO-2002036575-A1 | TAGGING COMPOUNDS AND PROCESS FOR USE IN AIDA LIBRARIES | NOVARTIS AG (CH) | 2002-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207715-A1 | Novel Inhibitors of Glutaminyl Cyclase | GLS, GLS2, GLUL | IDO1 1566/4885SRD5A2 2554/4885CYP1A2 1366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.