Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MYC | P01106 | 1/20 | 0.43 |
| ▸ | WDR5 | P61964 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | OXTR | P30559 | 1/20 | 0.41 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3536 | 1.00 | MEN1 (0.44) | MEN1KMT2AMYCWDR5RAB9A | |
| SCHEMBL2260 | 0.89 | ATM (0.42) | MEN1KMT2AMYCWDR5ALDH1A1 | |
| SCHEMBL3059 | 0.82 | CTSB (0.43) | MYCWDR5OXTRAVPR1AADAM17 | |
| SCHEMBL3057 | 0.82 | CTSB (0.43) | MYCWDR5OXTRAVPR1AADAM17 | |
| SCHEMBL2934 | 0.78 | GPR119 (0.43) | MEN1KMT2ARAB9AALDH1A1OXTR | |
| SCHEMBL2099 | 0.78 | LTB4R2 (0.55) | OXTRAVPR1AFFAR1AKR1B1OPRM1 | |
| SCHEMBL2100 | 0.78 | LTB4R2 (0.55) | OXTRAVPR1AFFAR1AKR1B1OPRM1 | |
| SCHEMBL8812256 | 0.78 | HRH3 (0.60) | MEN1KMT2ARAB9AOXTRAVPR1A | |
| SCHEMBL2103 | 0.75 | MYC (0.47) | MYCWDR5ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL9311469 | 0.75 | MME (0.44) | MYCWDR5OXTRAVPR1AADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965592-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1999-10-12 | — | — | US | disclosed |
| US-5399578-A | Hypotensive; valsartan; high blood pressure and cardiac insufficiency | CIBA-GEIGY CORP (US) | 1995-03-21 | — | — | US | disclosed |