Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G1B | P04054 | 1/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4078267 | 0.82 | PLA2G1B (0.61) | PLA2G1BPLA2G2ASIGMAR1 | |
| SCHEMBL6168746 | 0.79 | PLA2G1B (0.52) | PLA2G1BPLA2G2AALDH1A1 | |
| SCHEMBL10966563 | 0.78 | PLA2G1B (0.42) | PLA2G1BPLA2G2ASIGMAR1 | |
| SCHEMBL9330368 | 0.76 | PLA2G1B (0.50) | PLA2G1BPLA2G2AALDH1A1 | |
| SCHEMBL7379244 | 0.76 | PLA2G1B (0.43) | PLA2G1BPLA2G2ASIGMAR1 | |
| SCHEMBL10796465 | 0.75 | PLA2G1B (0.34) | PLA2G1BPLA2G2ASIGMAR1ALDH1A1 | |
| SCHEMBL20284332 | 0.74 | OPRM1 (0.42) | PLA2G1BPLA2G2ASIGMAR1ALDH1A1 | |
| SCHEMBL3715809 | 0.74 | OPRM1 (0.42) | PLA2G1BPLA2G2ASIGMAR1ALDH1A1 | |
| SCHEMBL15558498 | 0.74 | — | — | |
| SCHEMBL7786698 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101675082-B | Resin composition for optical material and optical material obtained from the resin composition | MITSUBISHI GAS CHEMICAL CO | 2012-04-04 | — | — | CN | disclosed |
| US-7829566-B2 | Such as (7-chloro-2-styryl-quinazolin-4-yl)-(3-imidazol-1-yl-propyl)-amine; glycoprotein antagonist; anticholesterol agents; cardiovascular disorders; strokes; antiischemic agents | MEDERSKI WERNER | 2010-11-09 | — | — | US | disclosed |
| US-20090118330-A1 | Diurea derivatives | ACTIVE BIOTECH AB (SE) | 2009-05-07 | — | — | US | disclosed |
| US-20070293667-A1 | 4-Amino-quinazolines | MEDERSKI WERNER | 2007-12-20 | — | — | US | disclosed |
| WO-2004030671-A2 | USE OF 4-AMINO-QUINAZOLINES AS ANTI CANCER AGENTS | MERCK PATENT GMBH (DE) | 2004-04-15 | — | — | WO | disclosed |
| US-20040044204-A1 | 4-amino-quinazolines | ORTHO-MCNEIL PHARMACEUTICALS, INC. | 2004-03-04 | — | — | US | disclosed |
| EP-1318985-A2 | 4-AMINO-QUINAZOLINES | MERCK PATENT GmbH (DE) | 2003-06-18 | — | — | EP | disclosed |
| US-20030109699-A1 | Amphiphilic quinolylpolyamines as transfer agents for biologically active macromolecules | G.O.T. THERAPEUTICS GMBH (DE) | 2003-06-12 | — | — | US | disclosed |
| EP-1244630-A1 | AMPHIPHILIC POLYAMINES, THE USE AND METHOD FOR SYNTHESIS THEREOF | G.O.T. Gesellschaft für Therapieoptimierung und Targeting Entwicklungs mbH (DE) | 2002-10-02 | — | — | EP | disclosed |
| WO-2002024666-A2 | 4-AMINO-QUINAZOLINES | MERCK PATENT GMBH (DE) | 2002-03-28 | — | — | WO | disclosed |
| WO-2001044198-A1 | AMPHIPHILIC QUINOLYLPOLYAMINES AS TRANSFER AGENTS FOR BIOLOGICALLY ACTIVE MACROMOLECULES | G.O.T. GESELLSCHAFT FÜR THERAPIEOPTIMIERUNG UND TARGETING ENTWICKLUNGS MBH (DE) | 2001-06-21 | — | — | WO | disclosed |
| US-4206144-A | N,N-Dialkyl-N-aminoalkyl-N-(amino or nitro)phenylalkyl- and N-methyl-N-[3-(amino or nitro)phenoxy-2-hydroxy-1-propyl]-N,N-bis(3-aminopropyl)quaternary ammonium salts | STERLING DRUG INC. (US) | 1980-06-03 | — | — | US | disclosed |
| US-4146558-A | Azo dyestuff intermediate nitro- or aminobenzenes ring-substituted by a quaternized amine alkyl or amino-alkoxy group | STERLING DRUG INC. (US) | 1979-03-27 | — | — | US | disclosed |
| US-4103092-A | Water-soluble quaternary ammonium non-heterocyclic azo dyestuffs | STERLING DRUG INC. (US) | 1978-07-25 | — | — | US | disclosed |
| US-4065500-A | Water-soluble quaternary ammonium azo dyestuffs | STERLING DRUG INC. (US) | 1977-12-27 | — | — | US | disclosed |
| US-3996282-A | Water-soluble quaternary ammonium dyestuffs | STERLING DRUG INC. (US) | 1976-12-07 | — | — | US | disclosed |
| US-3935182-A | Water-soluble quaternary ammonium heterocyclic azo dyestuffs | STERLING DRUG INC. (US) | 1976-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040044204-A1 | 4-amino-quinazolines | MRGPRX4, MRGPRX1, MRGPRX2 | PLA2G1B 3035/4885PLA2G2A 2338/4885SIGMAR1 26/4885 |
| US-20030109699-A1 | Amphiphilic quinolylpolyamines as transfer agents for biologically active macromolecules | POLRMT, HNRNPH3, HNRNPLL | PLA2G1B 1914/4885PLA2G2A 1227/4885SIGMAR1 1103/4885 |
| US-20090118330-A1 | Diurea derivatives | IL2, CASP2, MAVS | PLA2G1B 3912/4885PLA2G2A 3622/4885SIGMAR1 3068/4885 |
| US-20070293667-A1 | 4-Amino-quinazolines | MRGPRX4, MRGPRX1, MRGPRX2 | PLA2G1B 3036/4885PLA2G2A 2299/4885SIGMAR1 24/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.