Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Faxeladol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 9/20 | 0.50 |
| ▸ | SLC6A2 known ✓ | P23975 | 6/20 | 0.50 |
| ▸ | OPRM1 known ✓ | P35372 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Faxeladol SCHEMBL149508 | 1.00 | SLC6A4 (0.50) | SLC6A4SLC6A2OPRM1MEN1OPRD1 | |
| Faxeladol SCHEMBL5686250 | 1.00 | SLC6A4 (0.50) | SLC6A4SLC6A2OPRM1MEN1OPRD1 | |
| Faxeladol SCHEMBL30616185 | 1.00 | SLC6A4 (0.50) | SLC6A4SLC6A2OPRM1MEN1OPRD1 | |
| Faxeladol SCHEMBL149507 | 1.00 | SLC6A4 (0.50) | SLC6A4SLC6A2OPRM1MEN1OPRD1 | |
| Faxeladol SCHEMBL616828 | 1.00 | SLC6A4 (0.50) | SLC6A4SLC6A2OPRM1MEN1OPRD1 | |
| Faxeladol SCHEMBL12027609 | 1.00 | SLC6A4 (0.50) | SLC6A4SLC6A2OPRM1MEN1OPRD1 | |
| Faxeladol SCHEMBL28793358 | 1.00 | SLC6A4 (0.50) | SLC6A4SLC6A2OPRM1MEN1OPRD1 | |
| Faxeladol SCHEMBL7893759 | 0.99 | SLC6A4 (0.49) | SLC6A4SLC6A2OPRM1MEN1OPRD1 | |
| Faxeladol SCHEMBL619079 | 0.99 | SLC6A4 (0.49) | SLC6A4SLC6A2OPRM1MEN1OPRD1 | |
| Faxeladol SCHEMBL465057 | 0.99 | SLC6A4 (0.49) | SLC6A4SLC6A2OPRM1MEN1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1429754-B1 | COMBINATION OF SELECTED OPIOIDS WITH MUSCARINE ANTAGONISTS FOR TREATING URINARY INCONTINENCE | GRUENENTHAL GMBH (DE) | 2008-01-16 | — | — | EP | claimed |
| EP-1337246-B1 | USE OF 6-DIMETHYLAMINOMETHYL-1-PHENYL-CYCLOHEXANE COMPOUNDS FOR TREATING URINARY INCONTINENCE | GRUENENTHAL GMBH (DE) | 2006-03-22 | — | — | EP | claimed |
| EP-1562567-A1 | COMBINATION OF SELECTED ANALGESICS AND COX-II INHIBITORS | Grünenthal GmbH (DE) | 2005-08-17 | — | — | EP | claimed |
| US-20050137194-A1 | Combination of selected opioids with other active compounds for treatment of urinary incontinence | GRUENENTHAL GMBH (DE) | 2005-06-23 | — | — | US | claimed |
| US-6908944-B2 | Use of 6-dimethylaminomethyl-1-phenyl-cyclohexane compounds for treatment of urinary incontinence | GRUENENTHAL GMBH (DE) | 2005-06-21 | — | — | US | claimed |
| EP-1507520-A1 | COMBINATION OF SELECTED OPIOIDS WITH OTHER ACTIVE SUBSTANCES FOR USE IN THE THERAPY OF URINARY INCONTINENCE | Grünenthal GmbH (DE) | 2005-02-23 | — | — | EP | claimed |
| US-20040242617-A1 | active at very low doses, therefore low side effect profile | GRUENENTHAL GMBH (DE) | 2004-12-02 | — | — | US | claimed |
| EP-1429754-A1 | COMBINATION OF SELECTED OPIOIDS WITH MUSCARINE ANTAGONISTS FOR TREATING URINARY INCONTINENCE | Grünenthal GmbH (DE) | 2004-06-23 | — | — | EP | claimed |
| WO-2004047823-A1 | COMBINATION OF SELECTED ANALGESICS AND COX-II INHIBITORS | Grünenthal GmbH (DE) | 2004-06-10 | — | — | WO | claimed |
| US-20040043968-A1 | Use of 6-dimethylaminomethyl-1-phenyl-cyclohexane compounds for treatment of urinary incontinence | GRUENENTHAL GMBH (DE) | 2004-03-04 | — | — | US | claimed |
| WO-2003099268-A1 | COMBINATION OF SELECTED OPIOIDS WITH OTHER ACTIVE SUBSTANCES FOR USE IN THE THERAPY OF URINARY INCONTINENCE | Grünenthal GmbH (DE) | 2003-12-04 | — | — | WO | claimed |
| EP-1337246-A2 | USE OF 6-DIMETHYLAMINOMETHYL-1-PHENYL-CYCLOHEXANE COMPOUNDS FOR TREATING URINARY INCONTINENCE | Grünenthal GmbH (DE) | 2003-08-27 | — | — | EP | claimed |
| WO-2003024444-A1 | COMBINATION OF SELECTED OPIOIDS WITH MUSCARINE ANTAGONISTS FOR TREATING URINARY INCONTINENCE | Grünenthal GmbH (DE) | 2003-03-27 | — | — | WO | claimed |
| WO-2002043712-A2 | USE OF 6-DIMETHYLAMINOMETHYL-1-PHENYL-CYCLOHEXANE COMPOUNDS FOR TREATING URINARY INCONTINENCE | Grünenthal GmbH (DE) | 2002-06-06 | — | — | WO | claimed |
| EP-3241550-B1 | (1R, 2R)-3-(DIMENTHYL AMINO-1-ETHYL-2-METHYL-PROPYL) PHENOL FOR TREATING PAINFUL INFLAMMATIONS | GRUENENTHAL GMBH (DE) | 2020-07-22 | — | — | EP | disclosed |
| EP-3662904-A1 | USE OF (1R, 2R)-3-(DIMENTHYL AMINO-1-ETHYL-2-METHYL-PROPYL) PHENOL FOR TREATING PAINFUL INFLAMMATIONS | Grünenthal GmbH (DE) | 2020-06-10 | — | — | EP | disclosed |
| US-10471079-B2 | Combination of selected analgesics and COX-II inhibitors | GRUENENTHAL GMBH (DE) | 2019-11-12 | — | — | US | disclosed |
| EP-1337246-A2 | USE OF 6-DIMETHYLAMINOMETHYL-1-PHENYL-CYCLOHEXANE COMPOUNDS FOR TREATING URINARY INCONTINENCE | Grünenthal GmbH (DE) | 2003-08-27 | — | — | EP | disclosed |
| WO-2003024444-A1 | COMBINATION OF SELECTED OPIOIDS WITH MUSCARINE ANTAGONISTS FOR TREATING URINARY INCONTINENCE | Grünenthal GmbH (DE) | 2003-03-27 | — | — | WO | disclosed |
| WO-2002043712-A2 | USE OF 6-DIMETHYLAMINOMETHYL-1-PHENYL-CYCLOHEXANE COMPOUNDS FOR TREATING URINARY INCONTINENCE | Grünenthal GmbH (DE) | 2002-06-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242617-A1 | active at very low doses, therefore low side effect profile | OPRM1, OPRK1, OPRD1 | SLC6A4 406/4885SLC6A2 252/4885OPRM1 1/4885 |
| US-10471079-B2 | Combination of selected analgesics and COX-II inhibitors | OPRK1, PTGER2, OPRL1 | SLC6A4 2071/4885SLC6A2 1114/4885OPRM1 4/4885 |
| US-20050137194-A1 | Combination of selected opioids with other active compounds for treatment of urinary incontinence | OPRM1, OPRK1, OPRL1 | SLC6A4 131/4885SLC6A2 52/4885OPRM1 1/4885 |
| US-20040043968-A1 | Use of 6-dimethylaminomethyl-1-phenyl-cyclohexane compounds for treatment of urinary incontinence | UROD, DDC, ODC1 | SLC6A4 4036/4885SLC6A2 2371/4885OPRM1 110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.