Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Faxeladol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 9/20 | 0.50 |
| ▸ | SLC6A2 known ✓ | P23975 | 6/20 | 0.50 |
| ▸ | OPRM1 known ✓ | P35372 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Faxeladol SCHEMBL149508 | 1.00 | SLC6A4 (0.50) | SLC6A4SLC6A2OPRM1MEN1OPRD1 | |
| Faxeladol SCHEMBL5686250 | 1.00 | SLC6A4 (0.50) | SLC6A4SLC6A2OPRM1MEN1OPRD1 | |
| Faxeladol SCHEMBL354208 | 1.00 | SLC6A4 (0.50) | SLC6A4SLC6A2OPRM1MEN1OPRD1 | |
| Faxeladol SCHEMBL30616185 | 1.00 | SLC6A4 (0.50) | SLC6A4SLC6A2OPRM1MEN1OPRD1 | |
| Faxeladol SCHEMBL149507 | 1.00 | SLC6A4 (0.50) | SLC6A4SLC6A2OPRM1MEN1OPRD1 | |
| Faxeladol SCHEMBL12027609 | 1.00 | SLC6A4 (0.50) | SLC6A4SLC6A2OPRM1MEN1OPRD1 | |
| Faxeladol SCHEMBL28793358 | 1.00 | SLC6A4 (0.50) | SLC6A4SLC6A2OPRM1MEN1OPRD1 | |
| Faxeladol SCHEMBL7893759 | 0.99 | SLC6A4 (0.49) | SLC6A4SLC6A2OPRM1MEN1OPRD1 | |
| Faxeladol SCHEMBL619079 | 0.99 | SLC6A4 (0.49) | SLC6A4SLC6A2OPRM1MEN1OPRD1 | |
| Faxeladol SCHEMBL465057 | 0.99 | SLC6A4 (0.49) | SLC6A4SLC6A2OPRM1MEN1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928441-B1 | RETARDFORMULATION COMPRISING 3-(2-DIMETHYLAMINOMETHYLCYCLOHEXYL)PHENOL | GRUENENTHAL GMBH (DE) | 2013-02-27 | — | — | EP | disclosed |
| EP-1928441-B1 | RETARDFORMULATION COMPRISING 3-(2-DIMETHYLAMINOMETHYLCYCLOHEXYL)PHENOL | GRUENENTHAL GMBH (DE) | 2013-02-27 | — | — | EP | disclosed |
| US-20120039963-A1 | 3-(2-Dimethlaminomethyl Cyclohexyl)Phenol Retard Formulation | GRUENENTHAL GMBH (DE) | 2012-02-16 | — | — | US | disclosed |
| US-20120039963-A1 | 3-(2-Dimethlaminomethyl Cyclohexyl)Phenol Retard Formulation | GRUENENTHAL GMBH (DE) | 2012-02-16 | — | — | US | disclosed |
| US-20120039963-A1 | 3-(2-Dimethlaminomethyl Cyclohexyl)Phenol Retard Formulation | GRUENENTHAL GMBH (DE) | 2012-02-16 | — | — | US | disclosed |
| US-20110295038-A1 | Process for the Preparation of Substituted 1-aminomethyl-2-phenyl-cyclohexane Compounds | GRUENENTHAL GMBH (DE) | 2011-12-01 | — | — | US | disclosed |
| US-20110295038-A1 | Process for the Preparation of Substituted 1-aminomethyl-2-phenyl-cyclohexane Compounds | GRUENENTHAL GMBH (DE) | 2011-12-01 | — | — | US | disclosed |
| US-20110295038-A1 | Process for the Preparation of Substituted 1-aminomethyl-2-phenyl-cyclohexane Compounds | GRUENENTHAL GMBH (DE) | 2011-12-01 | — | — | US | disclosed |
| WO-2011147576-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED 1-AMINOMETHYL-2-PHENYL-CYCLOHEXANE COMPOUNDS | Grünenthal GmbH (DE) | 2011-12-01 | — | — | WO | disclosed |
| US-20090104266-A1 | 3-(2-DIMETHYLAMINOMETHYLCY CLOHEXYL)PHENOL RETARD FORMULATION | GRUENENTHAL GMBH (DE) | 2009-04-23 | — | — | US | disclosed |
| EP-1928441-A2 | 3-(2-DIMETHYLAMINOMETHYL CYCLOHEXYL) PHENOL RETARD FORMULATION | Grünenthal GmbH (DE) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007031326-A2 | 3-(2-DIMETHYLAMINOMETHYL CYCLOHEXYL) PHENOL RETARD FORMULATION | Grünenthal GmbH (DE) | 2007-03-22 | — | — | WO | disclosed |
| WO-2007031326-A2 | 3-(2-DIMETHYLAMINOMETHYL CYCLOHEXYL) PHENOL RETARD FORMULATION | Grünenthal GmbH (DE) | 2007-03-22 | — | — | WO | disclosed |
| EP-1337246-B1 | USE OF 6-DIMETHYLAMINOMETHYL-1-PHENYL-CYCLOHEXANE COMPOUNDS FOR TREATING URINARY INCONTINENCE | GRUENENTHAL GMBH (DE) | 2006-03-22 | — | — | EP | disclosed |
| US-6908944-B2 | Use of 6-dimethylaminomethyl-1-phenyl-cyclohexane compounds for treatment of urinary incontinence | GRUENENTHAL GMBH (DE) | 2005-06-21 | — | — | US | disclosed |
| US-20040043968-A1 | Use of 6-dimethylaminomethyl-1-phenyl-cyclohexane compounds for treatment of urinary incontinence | GRUENENTHAL GMBH (DE) | 2004-03-04 | — | — | US | disclosed |
| EP-1337246-A2 | USE OF 6-DIMETHYLAMINOMETHYL-1-PHENYL-CYCLOHEXANE COMPOUNDS FOR TREATING URINARY INCONTINENCE | Grünenthal GmbH (DE) | 2003-08-27 | — | — | EP | disclosed |
| WO-2002043712-A2 | USE OF 6-DIMETHYLAMINOMETHYL-1-PHENYL-CYCLOHEXANE COMPOUNDS FOR TREATING URINARY INCONTINENCE | Grünenthal GmbH (DE) | 2002-06-06 | — | — | WO | disclosed |
| EP-0753506-B1 | 6-Dimethylaminomethyl-1-phenyl-cyclo-hexane compounds as pharmaceutical agents | GRUENENTHAL GMBH (DE) | 1999-08-18 | — | — | EP | disclosed |
| EP-0753506-A1 | 6-Dimethylaminomethyl-1-phenyl-cyclo-hexane compounds as pharmaceutical agents | Grünenthal GmbH (DE) | 1997-01-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110295038-A1 | Process for the Preparation of Substituted 1-aminomethyl-2-phenyl-cyclohexane Compounds | ADRM1, PNMT, ACMSD | SLC6A4 2585/4885SLC6A2 1892/4885OPRM1 137/4885 |
| US-20120039963-A1 | 3-(2-Dimethlaminomethyl Cyclohexyl)Phenol Retard Formulation | MC2R, MC3R, HTR3C | SLC6A4 1653/4885SLC6A2 582/4885OPRM1 26/4885 |
| US-20040043968-A1 | Use of 6-dimethylaminomethyl-1-phenyl-cyclohexane compounds for treatment of urinary incontinence | UROD, DDC, ODC1 | SLC6A4 4036/4885SLC6A2 2371/4885OPRM1 110/4885 |
| US-20090104266-A1 | 3-(2-DIMETHYLAMINOMETHYLCY CLOHEXYL)PHENOL RETARD FORMULATION | QDPR, LBR, H1-0 | SLC6A4 3364/4885SLC6A2 2960/4885OPRM1 692/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.