SCHEMBL35449

SCHEMBL35449

CCC(=O)OC1=CC(=O)C=C2CC[C@@H]3[C@H]([C@@H](O)C[C@@]4(C)[C@H]3CC[C@]4(O)C(=O)CO)[C@]21C

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 12/20 0.64
NR3C1 P04150 6/20 0.64
HSD17B10 Q99714 5/20 0.64
PGR P06401 5/20 0.64
CYP3A4 P08684 5/20 0.64
CYP2C19 P33261 3/20 0.64
NR3C2 P08235 3/20 0.64
SERPINA6 P08185 3/20 0.64
AR P10275 2/20 0.64
ABCB11 O95342 2/20 0.64
TNF P01375 1/20 0.64
IL6 P05231 1/20 0.64
GLUL P15104 1/20 0.64
ADAM17 P78536 1/20 0.64
GPBAR1 Q8TDU6 1/20 0.64
SMN1; SMN2 Q16637 3/20 0.60
KMT2A Q03164 2/20 0.60
MAPT P10636 2/20 0.60
SHBG P04278 1/20 0.60
NFKB1 P19838 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27781029 0.95 HIF1A (0.66) HIF1ANR3C1HSD17B10PGRCYP3A4
SCHEMBL945988 0.94 HIF1A (0.65) HIF1ANR3C1HSD17B10PGRCYP3A4
SCHEMBL11068491 0.93 HIF1A (0.62) HIF1ANR3C1HSD17B10PGRCYP3A4
SCHEMBL264554 0.93 HIF1A (0.64) HIF1ANR3C1HSD17B10PGRCYP3A4
SCHEMBL677626 0.93 HIF1A (0.61) HIF1ANR3C1HSD17B10PGRCYP3A4
SCHEMBL2326922 0.92 HIF1A (0.63) HIF1ANR3C1HSD17B10PGRCYP3A4
SCHEMBL28480766 0.92 HIF1A (0.67) HIF1ANR3C1HSD17B10PGRCYP3A4
SCHEMBL5955148 0.92 HIF1A (0.62) HIF1ANR3C1HSD17B10PGRCYP3A4
SCHEMBL3285984 0.91 HIF1A (0.66) HIF1ANR3C1HSD17B10PGRCYP3A4
SCHEMBL5484066 0.91 HIF1A (0.60) HIF1ANR3C1HSD17B10PGRCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 383 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117599290-A Pressurized metered dose inhaler comprising buffered pharmaceutical formulation 奇斯药制品公司 2024-02-27 CN claimed
CN-116098866-A Glucocorticoid fat emulsion for treating arthralgia, preparation method and application thereof 中南大学湘雅医院 2023-05-12 CN claimed
CN-109963818-B Method for air-quenching an elongated hollow glass body comprising an axial hole 克鲁斯杰克特公司 2022-06-03 CN claimed
US-20180071390-A1 COMPOSITIONS OF PHARMACEUTICAL ACTIVES CONTAINING DIETHYLENE GLYCOL MONOETHYL ETHER OR OTHER ALKYL DERIVATIVES THEMIS MEDICARE LIMITED (IN) 2018-03-15 US claimed
US-9827315-B2 Compositions of pharmaceutical actives containing diethylene glycol monoethyl ether or other alkyl derivatives THEMIS MEDICARE LIMITED (IN) 2017-11-28 US claimed
WO-2014178065-A1 COMPOSITIONS OF PHARMACEUTICAL ACTIVES CONTAINING DIETHYLENE GLYCOL MONOETHYL ETHER OR OTHER ALKYL DERIVATIVES THEMIS MEDICARE LIMITED (IN) 2014-11-06 WO claimed
US-20140296191-A1 COMPOSITIONS OF PHARMACEUTICAL ACTIVES CONTAINING DIETHYLENE GLYCOL MONOETHYL ETHER OR OTHER ALKYL DERIVATIVES THEMIS MEDICARE LIMITED (IN) 2014-10-02 US claimed
US-4478818-A Ocular preparation housing steroid in two different therapeutic forms ALZA CORPORATION (US) 1984-10-23 US claimed
US-20260144674-A1 Apparatus and Methods for Drug Delivery Using Microneedles CLEARSIDE BIOMEDICAL, INC. (US) 2026-05-28 US disclosed
EP-3622820-B1 STABLE HYALURONAN/STEROID FORMULATION GENZYME CORP (US) 2026-02-18 EP disclosed
US-20250345206-A1 APPARATUS AND METHODS FOR OCULAR INJECTION CLEARSIDE BIOMEDICAL, INC. (US) 2025-11-13 US disclosed
US-12350261-B2 Methods and devices for the treatment of ocular diseases in human subjects CLEARSIDE BIOMEDICAL, INC. (US) 2025-07-08 US disclosed
US-20250186253-A1 DEVICES AND METHODS FOR ADJUSTING THE INSERTION DEPTH OF A NEEDLE FOR MEDICAMENT DELIVERY CLEARSIDE BIOMEDICAL, INC. (US) 2025-06-12 US disclosed
EP-4566672-A2 METHODS FOR THE TREATMENT OF OCULAR DISEASE IN HUMAN SUBJECTS Clearside Biomedical Inc. (US) 2025-06-11 EP disclosed
US-4088756-A TREATING PSORIASIS, DERMATITIS WITH ADRENERGIC AGENTS AND HYPOGLYCEMIC AGENTS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 1978-05-09 US disclosed
US-4034087-A TREATING PROLIFERATIVE SKIN DISEASES WITH 4-BENZYL-2-IMIDAZOLIDONES THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 1977-07-05 US disclosed
US-4018927-A Treatment of proliferating skin diseases with papaverine alkaloids THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 1977-04-19 US disclosed
US-4009282-A Treatment of proliferating skin diseases with prostaglandins THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 1977-02-22 US disclosed
US-4007268-A Process for alleviating proliferative skin diseases THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 1977-02-08 US disclosed
US-3962430-A Sterilization of solid non-electrolyte medicinal agents employing sodium chloride MERCK & CO., INC. (US) 1976-06-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180071390-A1 COMPOSITIONS OF PHARMACEUTICAL ACTIVES CONTAINING DIETHYLENE GLYCOL MONOETHYL ETHER OR OTHER ALKYL DERIVATIVES DSG1, DEGS1, PLA2G2E HIF1A 3779/4885NR3C1 614/4885HSD17B10 2421/4885
US-20260144674-A1 Apparatus and Methods for Drug Delivery Using Microneedles PROKR2, SLC10A2, GLP1R HIF1A 3761/4885NR3C1 2701/4885HSD17B10 3792/4885
US-20140296191-A1 COMPOSITIONS OF PHARMACEUTICAL ACTIVES CONTAINING DIETHYLENE GLYCOL MONOETHYL ETHER OR OTHER ALKYL DERIVATIVES DSG1, DEGS1, PLA2G2E HIF1A 3779/4885NR3C1 614/4885HSD17B10 2421/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.