Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.42 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 3/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.35 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4374233 | 0.80 | CHRNB2 (0.40) | KDM1AKDM1BHTR2CHTR2BHTR2A | |
| SCHEMBL2204913 | 0.79 | HTR2C (0.47) | KDM1AHTR2CHTR2BHTR2ATNKS2 | |
| SCHEMBL10682669 | 0.79 | CHRNB2 (0.37) | HTR2CHTR2BHTR2ACHRNB2CHRNA4 | |
| SCHEMBL1254662 | 0.79 | TAAR1 (0.41) | HTR2CHTR2BHTR2ATNKS2HTR1A | |
| SCHEMBL1255269 | 0.79 | HTR2C (0.51) | HTR2CHTR2BHTR2ACHRNB2CHRNA4 | |
| SCHEMBL1254418 | 0.77 | KDM1A (0.45) | KDM1AHTR2AHTR1ASLC6A2NISCH | |
| SCHEMBL1254378 | 0.76 | HTR2C (0.51) | HTR2CHTR2BHTR2AHTR1ASLC6A2 | |
| SCHEMBL2199708 | 0.76 | HTR2C (0.41) | KDM1AHTR2CHTR2BHTR2ASLC6A2 | |
| SCHEMBL571789 | 0.74 | SLC18A3 (0.41) | KDM1ANISCHTAAR1 | |
| SCHEMBL1255263 | 0.73 | HTR2C (0.50) | HTR2CHTR2BHTR2ASLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8809369-B2 | Tetrahydroquinoline derivatives | HOFFMANN-LA ROCHE INC. (US) | 2014-08-19 | — | — | US | claimed |
| EP-2678327-A1 | HETEROARYL DERIVATIVES AS ALPHA7 NACHR MODULATORS | Lupin Limited (IN) | 2014-01-01 | — | — | EP | claimed |
| EP-2668165-A1 | NOVEL TETRAHYDROQUINOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-12-04 | — | — | EP | claimed |
| WO-2012114285-A9 | HETEROARYL DERIVATIVES AS ALPHA7 NACHR MODULATORS | LUPIN LIMITED (IN) | 2012-10-18 | — | — | WO | claimed |
| WO-2012114285-A1 | HETEROARYL DERIVATIVES AS ALPHA7 NACHR MODULATORS | LUPIN LIMITED (IN) | 2012-08-30 | — | — | WO | claimed |
| WO-2012101068-A1 | NOVEL TETRAHYDROQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-08-02 | — | — | WO | claimed |
| US-20120190677-A1 | NOVEL TETRAHYDROQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | US | claimed |
| US-7439238-B2 | Antiparasitic artemisinin derivatives (endoperoxides) | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (HK) | 2008-10-21 | — | — | US | claimed |
| US-20070191354-A1 | Antiparasitic artemisinin derivatives (endoperoxides) | BAYER AKTIENGESELLSCHAFT (DE) | 2007-08-16 | — | — | US | claimed |
| US-20070021409-A1 | Antiparasitic artemisinin derivatives (endoperoxides) | BAYER AKTIENGESELLSCHAFT (DE) | 2007-01-25 | — | — | US | claimed |
| EP-1095042-B9 | ANTIPARASITIC ARTEMISININ DERIVATIVES (ENDOPEROXIDES) | BAYER HEALTHCARE AG (DE) | 2006-07-05 | — | — | EP | claimed |
| EP-1655302-A2 | ANTIPARASITIC ARTEMISININ DERIVATIVES (ENDOPEROXIDES) | Bayer HealthCare AG (DE) | 2006-05-10 | — | — | EP | claimed |
| EP-1095042-B1 | ANTIPARASITIC ARTEMISININ DERIVATIVES (ENDOPEROXIDES) | BAYER HEALTHCARE AG (DE) | 2005-12-28 | — | — | EP | claimed |
| EP-1095042-A1 | ANTIPARASITIC ARTEMISININ DERIVATIVES (ENDOPEROXIDES) | Bayer Aktiengesellschaft (DE) | 2001-05-02 | — | — | EP | claimed |
| WO-2000004024-A1 | ANTIPARASITIC ARTEMISININ DERIVATIVES (ENDOPEROXIDES) | BAYER AKTIENGESELLSCHAFT (DE) | 2000-01-27 | — | — | WO | claimed |
| US-10111884-B2 | Methods and compositions for treating viral infections | HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. (IL) | 2018-10-30 | — | — | US | disclosed |
| EP-2838903-B1 | METHODS AND COMPOSITIONS FOR TREATING VIRAL INFECTIONS | UNIV HONG KONG SCIENCE & TECH (CN) | 2017-09-06 | — | — | EP | disclosed |
| EP-1095043-A1 | TRIOXANE DERIVATIVES | The Hong Kong University of Science & Technology (HK) | 2001-05-02 | — | — | EP | disclosed |
| WO-2000004024-A1 | ANTIPARASITIC ARTEMISININ DERIVATIVES (ENDOPEROXIDES) | BAYER AKTIENGESELLSCHAFT (DE) | 2000-01-27 | — | — | WO | disclosed |
| WO-2000004026-A1 | TRIOXANE DERIVATIVES | THE HONG KONG UNIVERSITY OF SCIENCE & TECHNOLOGY (CN) | 2000-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10111884-B2 | Methods and compositions for treating viral infections | MAVS, EIF2AK2, HAVCR2 | KDM1A 2648/4885KDM1B 2494/4885NOS3 568/4885 |
| US-20120190677-A1 | NOVEL TETRAHYDROQUINOLINE DERIVATIVES | RAB1A, RABL3, RAB7A | KDM1A 621/4885KDM1B 1129/4885NOS3 411/4885 |
| US-20070021409-A1 | Antiparasitic artemisinin derivatives (endoperoxides) | DHPS, CASP10, FECH | KDM1A 4297/4885KDM1B 4691/4885NOS3 249/4885 |
| US-20070191354-A1 | Antiparasitic artemisinin derivatives (endoperoxides) | DHPS, CASP10, FECH | KDM1A 4297/4885KDM1B 4691/4885NOS3 249/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.