Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 1/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 5/20 | 0.42 |
| ▸ | CD38 | P28907 | 2/20 | 0.37 |
| ▸ | F2 | P00734 | 2/20 | 0.36 |
| ▸ | F10 | P00742 | 2/20 | 0.36 |
| ▸ | F7 | P08709 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 5/20 | 0.35 |
| ▸ | AURKA | O14965 | 4/20 | 0.35 |
| ▸ | MET | P08581 | 4/20 | 0.35 |
| ▸ | TEK | Q02763 | 4/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL353654 | 0.85 | HSD17B2 (0.43) | HSD17B1HSD17B2KDM4EALDH1A1GAA | |
| SCHEMBL634882 | 0.79 | KDM4E (0.65) | HSD17B1HSD17B2KDM4EALDH1A1GAA | |
| SCHEMBL352442 | 0.78 | F2 (0.42) | KDM4EALDH1A1GAAPARP1F2 | |
| SCHEMBL634716 | 0.78 | KDM4E (0.53) | HSD17B1HSD17B2KDM4EALDH1A1GAA | |
| SCHEMBL353378 | 0.75 | F10 (0.48) | KDM4EALDH1A1GAAPARP1F2 | |
| SCHEMBL14134550 | 0.75 | HPGD (0.47) | HSD17B1HSD17B2KDM4EALDH1A1PARP1 | |
| SCHEMBL241944 | 0.74 | KDM4E (0.44) | KDM4EALDH1A1GAAPARP1F2 | |
| SCHEMBL10274480 | 0.73 | KDM4E (0.61) | KDM4EALDH1A1GAAPARP1KDR | |
| SCHEMBL353489 | 0.72 | ALDH1A1 (0.53) | HSD17B1HSD17B2KDM4EALDH1A1GAA | |
| SCHEMBL14134468 | 0.70 | PARP1 (0.47) | HSD17B1HSD17B2PARP1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120015992-A1 | Napthalene-Based Inhibitors of Anti-Apoptotic Proteins | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2012-01-19 | — | — | US | disclosed |
| US-8039668-B2 | Naphthalene-based inhibitors of anti-apoptotic proteins | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2011-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015992-A1 | Napthalene-Based Inhibitors of Anti-Apoptotic Proteins | HAX1, PRDX1, APOL1 | HSD17B1 569/4885HSD17B2 992/4885KDM4E 4564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.