Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.48 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.42 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31735937 | 1.00 | MAPK1 (0.49) | MAPK1TSHRKIF18AVCAM1MAPT | |
| SCHEMBL7782688 | 0.85 | MAPK1 (0.47) | MAPK1TSHRKIF18AVCAM1MAPT | |
| SCHEMBL7658698 | 0.83 | CYP1A2 (0.55) | MAPK1TSHRMAPTSMN1; SMN2FLT1 | |
| SCHEMBL357928 | 0.79 | PDK1 (0.55) | MAPK1TSHRKIF18AVCAM1MAPT | |
| SCHEMBL67686 | 0.79 | ALDH1A1 (0.58) | MAPK1TSHRKIF18AVCAM1MAPT | |
| SCHEMBL270126 | 0.77 | ALDH1A1 (0.61) | MAPK1TSHRMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL67536 | 0.77 | MAPK1 (0.53) | MAPK1TSHRKIF18AVCAM1MAPT | |
| SCHEMBL535352 | 0.77 | MAPK1 (0.53) | MAPK1TSHRKIF18AVCAM1MAPT | |
| SCHEMBL31424902 | 0.77 | ALDH1A1 (0.61) | MAPK1TSHRMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL2112011 | 0.77 | MAPK1 (0.53) | MAPK1TSHRKIF18AVCAM1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101628888-B | Inhibitors of cytosolic phospholipase a2 | WYETH CORP | 2012-05-23 | — | — | CN | disclosed |
| US-7713964-B2 | Methods for treating asthmatic conditions | WYETH LLC (US) | 2010-05-11 | — | — | US | disclosed |
| US-7605156-B2 | Methods for the use of inhibitors of cytosolic phospholipase A2 | WYETH (US) | 2009-10-20 | — | — | US | disclosed |
| CN-100503566-C | Cytosolic phospholipase A2 inhibitors | WYETH CORP (US) | 2009-06-24 | — | — | CN | disclosed |