Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.40 |
| ▸ | PEPD | P12955 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6079845 | 0.90 | MEN1 (0.43) | ALDH1A1MAPTHSD17B10PRKCIPEPD | |
| SCHEMBL9494042 | 0.82 | LMNA (0.50) | ALDH1A1MAPTHSD17B10NPC1MEN1 | |
| SCHEMBL27627388 | 0.79 | PRKCI (0.63) | ALDH1A1MAPTHSD17B10PRKCIPEPD | |
| SCHEMBL25448024 | 0.78 | ALDH1A1 (0.40) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL25448023 | 0.78 | MAPT (0.50) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL6079794 | 0.76 | MEN1 (0.41) | ALDH1A1MAPTHSD17B10PRKCIKIF11 | |
| SCHEMBL6502347 | 0.74 | PRKCI (0.53) | ALDH1A1MAPTPRKCIPEPDKIF11 | |
| SCHEMBL1787750 | 0.73 | PEPD (0.56) | ALDH1A1MAPTHSD17B10PEPDKIF11 | |
| SCHEMBL17682674 | 0.73 | POLB (0.45) | ALDH1A1MAPTHSD17B10NPC1MEN1 | |
| SCHEMBL11178821 | 0.70 | KIF11 (0.51) | ALDH1A1MAPTHSD17B10PRKCIKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7750161-B2 | Pyridine derivatives | ACTELION PHARMACEUTICALS, LTD. (CH) | 2010-07-06 | — | — | US | disclosed |
| US-20070043081-A1 | Novel pyridine derivatives | ACTELION PHARMACEUTICALS, LTD. (CH) | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043081-A1 | Novel pyridine derivatives | P2RY4, P2RX6, P2RX4 | ALDH1A1 2078/4885MAPT 1151/4885HSD17B10 3481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.