Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | MTOR | P42345 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7769268 | 0.92 | OPRM1 (0.41) | OPRM1OPRD1SLC6A4MEN1KMT2A | |
| SCHEMBL3802 | 0.82 | OPRM1 (0.48) | OPRM1OPRD1SLC6A4MEN1KMT2A | |
| SCHEMBL10359727 | 0.81 | SLC7A5 (0.52) | OPRM1SLC6A4MEN1KMT2ALMNA | |
| SCHEMBL4739538 | 0.81 | SLC6A9 (0.52) | OPRM1SLC6A4MEN1KMT2ALMNA | |
| SCHEMBL4739366 | 0.80 | SLC6A9 (0.53) | OPRM1SLC6A4MEN1KMT2ALMNA | |
| SCHEMBL3981 | 0.78 | HTR1A (0.46) | OPRM1SLC6A4MEN1KMT2ALMNA | |
| Oxalic Acid SCHEMBL3554 | 0.78 | SLC6A4 (0.62) | OPRM1OPRD1SLC6A4MEN1KMT2A | |
| SCHEMBL4736674 | 0.78 | PDE2A (0.43) | OPRM1SLC6A4MEN1KMT2ALMNA | |
| Maleic Acid SCHEMBL7769265 | 0.75 | SLC6A4 (0.58) | OPRM1OPRD1SLC6A4MEN1KMT2A | |
| Fumaric Acid SCHEMBL7769270 | 0.75 | SLC6A4 (0.58) | OPRM1OPRD1SLC6A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5023269-A | 3-aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1991-06-11 | — | — | US | disclosed |
| EP-0273658-B1 | 3-ARYLOXY-3-SUBSTITUTED PROPANAMINES | ELI LILLY AND COMPANY (US) | 1990-10-31 | — | — | EP | disclosed |
| US-4956388-A | ANTIDEPRESSANTS, ANTIANXIETY, TREATMENT OF OBESITY, ADDICTION TO SMOKING AND ALCOHOL | ELI LILLY AND COMPANY (US) | 1990-09-11 | — | — | US | disclosed |