Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3064562 | 1.00 | POLB (0.50) | POLBLTA4HPTGS2LMNAKMT2A | |
| SCHEMBL3064563 | 1.00 | POLB (0.50) | POLBLTA4HPTGS2LMNAKMT2A | |
| Hydrochloric Acid SCHEMBL3067119 | 0.99 | POLB (0.49) | POLBLTA4HPTGS2LMNAKMT2A | |
| Hydrochloric Acid SCHEMBL3067120 | 0.99 | POLB (0.49) | POLBLTA4HPTGS2LMNAKMT2A | |
| Hydrochloric Acid SCHEMBL7218972 | 0.99 | POLB (0.49) | POLBLTA4HPTGS2LMNAKMT2A | |
| SCHEMBL5698976 | 0.87 | ALDH1A1 (0.53) | POLBLTA4HPTGS2LMNAKMT2A | |
| Hydrochloric Acid SCHEMBL3055264 | 0.86 | ALDH1A1 (0.53) | POLBLTA4HPTGS2LMNAKMT2A | |
| SCHEMBL7206301 | 0.82 | HRH3 (0.52) | LTA4HHRH3ALDH1A1KDM4ERAB9A | |
| SCHEMBL7206298 | 0.82 | HRH3 (0.52) | LTA4HHRH3ALDH1A1KDM4ERAB9A | |
| Hydrochloric Acid SCHEMBL7201657 | 0.81 | HRH3 (0.51) | LTA4HSLC6A2HRH3ALDH1A1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003045387-A1 | PHARMACEUTICAL COMPOSITION WITH COMBINED ACTIVE AGENTS CONTAINING METFORMIN AND A HYDROXYLAMINE DERIVATIVE | BIOREX KUTATÓ ÉS FEJLESZTÖ RT. (HU) | 2003-06-05 | — | — | WO | claimed |
| US-7691849-B2 | Carboxamidine derivatives and their use in the treatment of vascular diseases | CYTRX CORPORATION (US) | 2010-04-06 | — | — | US | disclosed |
| US-20090253690-A1 | PHARMACEUTICALLY EFFECTIVE COMPOUNDS | CYTRX CORPORATION (US) | 2009-10-08 | — | — | US | disclosed |
| US-7550457-B2 | Pharmaceutically effective compounds | CYTRX CORPORATION (US) | 2009-06-23 | — | — | US | disclosed |
| US-20090075993-A1 | Pharmaceutically effective compounds | KEMPHARM, INC. | 2009-03-19 | — | — | US | disclosed |
| US-7384936-B2 | Carboxamidine derivatives and their use in the treatment of vascular diseases | CYTRX CORPORATION (US) | 2008-06-10 | — | — | US | disclosed |
| US-7361655-B2 | Pharmaceutically effective compounds | CYTRX CORPORATION (US) | 2008-04-22 | — | — | US | disclosed |
| US-20080058323-A1 | PHARMACEUTICALLY EFFECTIVE COMPOUNDS | KEMPHARM, INC. | 2008-03-06 | — | — | US | disclosed |
| EP-0966283-B1 | PHARMACEUTICAL PRODUCTS FOR CURING AND PREVENTING DISEASES RESULTING FROM THE DAMAGING OF THE VASCULAR ENDOTHELIAL CELLS | CYTRX CORP (US) | 2006-06-14 | — | — | EP | disclosed |
| US-20060058294-A1 | Carboxamidine derivatives and their use in the treatment of vascular diseases | KEMPHARM, INC. | 2006-03-16 | — | — | US | disclosed |
| US-20050043295-A1 | Pharmaceutically effective compounds | KEMPHARM, INC. | 2005-02-24 | — | — | US | disclosed |
| EP-1492763-A1 | CARBOXAMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF VASCULAR DISEASES | BIOREX KUTATO ES FEJLESZTÖ RT. (HU) | 2005-01-05 | — | — | EP | disclosed |
| WO-2003057664-A1 | CARBOXAMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF VASCULAR DISEASES | BIOREX KUTATÓ ÉS FEJLESZTÖ RT. (HU) | 2003-07-17 | — | — | WO | disclosed |
| WO-2003045387-A1 | PHARMACEUTICAL COMPOSITION WITH COMBINED ACTIVE AGENTS CONTAINING METFORMIN AND A HYDROXYLAMINE DERIVATIVE | BIOREX KUTATÓ ÉS FEJLESZTÖ RT. (HU) | 2003-06-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253690-A1 | PHARMACEUTICALLY EFFECTIVE COMPOUNDS | PCSK9, SIRT5, ADCY5 | POLB 3122/4885LTA4H 809/4885PTGS2 497/4885 |
| US-20090075993-A1 | Pharmaceutically effective compounds | SIRT5, PCSK9, CNR2 | POLB 3442/4885LTA4H 543/4885PTGS2 618/4885 |
| US-20060058294-A1 | Carboxamidine derivatives and their use in the treatment of vascular diseases | SIRT5, PDXK, TEK | POLB 1949/4885LTA4H 1242/4885PTGS2 881/4885 |
| US-20050043295-A1 | Pharmaceutically effective compounds | PCSK9, SIRT5, ADCY5 | POLB 3122/4885LTA4H 809/4885PTGS2 497/4885 |
| US-20080058323-A1 | PHARMACEUTICALLY EFFECTIVE COMPOUNDS | PCSK9, SIRT5, ADCY5 | POLB 3122/4885LTA4H 809/4885PTGS2 497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.