Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | TYK2 | P29597 | 2/20 | 0.33 |
| ▸ | STAT3 | P40763 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3566255 | 0.81 | ALDH1A1 (0.41) | MEN1KMT2ASMN1; SMN2MAPK10MAPK9 | |
| SCHEMBL3570859 | 0.78 | MAPK10 (0.38) | MEN1GAAKMT2ASMN1; SMN2MAPK10 | |
| SCHEMBL3562691 | 0.78 | MAPK10 (0.52) | MAPK10MAPK9LMNAMAPK8 | |
| SCHEMBL3572889 | 0.76 | CCNT1 (0.42) | MEN1GAAKMT2ASMN1; SMN2MAPK10 | |
| SCHEMBL3565626 | 0.76 | ALDH1A1 (0.41) | MEN1GAAKMT2ASMN1; SMN2LMNA | |
| SCHEMBL3566316 | 0.75 | AXL (0.41) | MEN1GAAKMT2ASMN1; SMN2SCN8A | |
| SCHEMBL5622159 | 0.74 | TSHR (0.42) | MEN1GAAKMT2AMAPK9MAPT | |
| SCHEMBL3569022 | 0.74 | GPR39 (0.41) | MEN1KMT2AFLT3TYRO3MERTK | |
| SCHEMBL3572008 | 0.74 | SMN1; SMN2 (0.35) | MEN1GAAKMT2ASMN1; SMN2MAPK10 | |
| SCHEMBL3562759 | 0.73 | CDK9 (0.40) | MEN1GAAKMT2ASMN1; SMN2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633363-B1 | PYRIDINYL ACETONITRILES | MERCK SERONO SA (CH) | 2012-11-07 | — | — | EP | claimed |
| US-7855212-B2 | Pyridinyl acetonitriles | MERCK SERONO SA (CH) | 2010-12-21 | — | — | US | claimed |
| US-20070060594-A1 | Pyridinyl acetonitriles | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2007-03-15 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060594-A1 | Pyridinyl acetonitriles | GSK3B, GSK3A, MAPK3 | MEN1 3686/4885GAA 2009/4885KMT2A 4507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.