Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 3/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 2/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.37 |
| ▸ | MERTK | Q12866 | 2/20 | 0.37 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.37 |
| ▸ | STAT6 | P42226 | 5/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | FCGR3B | O75015 | 1/20 | 0.32 |
| ▸ | FCGR1A | P12314 | 1/20 | 0.32 |
| ▸ | FCGR2A | P12318 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3572889 | 0.89 | CCNT1 (0.42) | MAPK10MAPK9MAPK8MEN1GAA | |
| SCHEMBL3562691 | 0.86 | MAPK10 (0.52) | MAPK10MAPK9MAPK8MKNK1MKNK2 | |
| SCHEMBL3566255 | 0.86 | ALDH1A1 (0.41) | MAPK10MAPK9MAPK8HTR7MEN1 | |
| SCHEMBL5622159 | 0.79 | TSHR (0.42) | MAPK9MEN1GAAKMT2A | |
| SCHEMBL3558059 | 0.78 | MEN1 (0.34) | MAPK10MAPK9MAPK8AXLTYRO3 | |
| SCHEMBL3565626 | 0.77 | ALDH1A1 (0.41) | MEN1GAAKMT2ASMN1; SMN2 | |
| SCHEMBL3569022 | 0.75 | GPR39 (0.41) | AXLTYRO3MERTKFLT3GAS6 | |
| SCHEMBL3572008 | 0.75 | SMN1; SMN2 (0.35) | MAPK10MAPK9MAPK8MEN1GAA | |
| SCHEMBL3562759 | 0.74 | CDK9 (0.40) | AXLTYRO3MERTKFLT3GAS6 | |
| SCHEMBL3566316 | 0.73 | AXL (0.41) | AXLTYRO3MERTKFLT3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7855212-B2 | Pyridinyl acetonitriles | MERCK SERONO SA (CH) | 2010-12-21 | — | — | US | claimed |
| US-20070060594-A1 | Pyridinyl acetonitriles | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2007-03-15 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060594-A1 | Pyridinyl acetonitriles | GSK3B, GSK3A, MAPK3 | MAPK10 86/4885MAPK9 105/4885MAPK8 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.