Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.53 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL932848 | 0.83 | ALOX15 (0.53) | ALDH1A1MAPTKDM4EHPGDNPC1 | |
| SCHEMBL2417969 | 0.83 | ALDH1A1 (0.49) | ALDH1A1MAPTKDM4EHPGDTSHR | |
| SCHEMBL6246471 | 0.81 | MAPT (0.42) | ALDH1A1MAPTKDM4EHPGDTSHR | |
| SCHEMBL8109418 | 0.81 | MAPT (0.42) | ALDH1A1MAPTKDM4EHPGDTSHR | |
| SCHEMBL1023432 | 0.81 | ALDH1A1 (0.42) | ALDH1A1MAPTKDM4EHPGDTSHR | |
| SCHEMBL11678330 | 0.81 | HCRTR1 (0.44) | ALDH1A1MAPTKDM4EHPGDTSHR | |
| SCHEMBL28522655 | 0.81 | KDM4E (0.53) | ALDH1A1MAPTKDM4EHPGDTSHR | |
| Zinc Ion SCHEMBL10405317 | 0.80 | HCRTR1 (0.42) | ALDH1A1MAPTKDM4EHPGDTSHR | |
| SCHEMBL30344049 | 0.79 | KDM4E (0.43) | ALDH1A1MAPTKDM4EHPGDTSHR | |
| SCHEMBL4089638 | 0.79 | MYC (0.44) | ALDH1A1MAPTKDM4EHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106831285-B | Method for converting amide and urea into ester | 湖北科技学院 | 2020-08-11 | — | — | CN | claimed |
| CN-101636073-A | The seed of bag quilt and manufacturing bag are by the method for seed | VAMTECH L L C | 2010-01-27 | — | — | CN | claimed |
| EP-2035386-A1 | ISOQUINOLINE DERIVATIVES AND THEIR USE AS INHIBITORS OF CYTOKINE MEDIATED DISEASES | AstraZeneca AB (SE) | 2009-03-18 | — | — | EP | claimed |
| WO-2007149031-A1 | ISOQUINOLINE DERIVATIVES AND THEIR USE AS INHIBITORS OF CYTOKINE MEDIATED DISEASES | ASTRAZENECA AB (SE) | 2007-12-27 | — | — | WO | claimed |
| EP-1807406-A2 | INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-18 | — | — | EP | claimed |
| WO-2006047503-A2 | INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA (BE) | 2006-05-04 | — | — | WO | claimed |
| US-20050113566-A1 | Inhibitors of C-FMS kinase | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-05-26 | — | — | US | claimed |
| US-20230116770-A1 | SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute | 2023-04-13 | — | — | US | disclosed |
| US-11452717-B2 | Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof | Sanford Burnham Prebys Medical Discovery Institute (US) | 2022-09-27 | — | — | US | disclosed |
| CN-106831285-B | Method for converting amide and urea into ester | 湖北科技学院 | 2020-08-11 | — | — | CN | disclosed |
| EP-3568390-A1 | SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2019-11-20 | — | — | EP | disclosed |
| WO-2018132372-A1 | SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2018-07-19 | — | — | WO | disclosed |
| CN-105949161-B | A kind of preparation method of 3- aromatic thiohydroxies chromocor compound | 温州大学 | 2018-05-15 | — | — | CN | disclosed |
| US-20050113566-A1 | Inhibitors of C-FMS kinase | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-05-26 | — | — | US | disclosed |
| CN-1150198-C | Process for producing hexahydrothiopheno-[3,4-d] imidazole-2,4-diketones compound | 住友化学工业株式会社 | 2004-05-19 | — | — | CN | disclosed |
| CN-1277200-A | Process for producing hexahydrothiopheno-[3,4-d] imidazole-2,4-diketones compound | SUMITOMO KAGAKU KOGYO K K (JP) | 2000-12-20 | — | — | CN | disclosed |
| EP-0804420-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | American Cyanamid Company (US) | 1997-11-05 | — | — | EP | disclosed |
| US-4199360-A | DISSOLVING METHINE DYE IN PRESENCE OF RED SHIFT COMPOUND | FUJI PHOTO FILM CO., LTD. (JP) | 1980-04-22 | — | — | US | disclosed |
| US-4138266-A | SULFO-SUBSTITUTED CYANINE AND RED SHIFT TRIAZOLE DYES | FUJI PHOTO FILM CO., LTD. (JP) | 1979-02-06 | — | — | US | disclosed |
| US-4046572-A | SILVER HALIDE PHOTOGRAPHIC LIGHT SENSITIVE MATERIAL | FUJI PHOTO FILM CO., LTD. (JA) | 1977-09-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11452717-B2 | Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof | NAMPT, NAPRT, NNT | ALDH1A1 1943/4885MAPT 369/4885KDM4E 3620/4885 |
| US-20230116770-A1 | SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF | NAMPT, NAPRT, NNT | ALDH1A1 1943/4885MAPT 369/4885KDM4E 3620/4885 |
| US-20050113566-A1 | Inhibitors of C-FMS kinase | ALK, TYRO3, PDGFRB | ALDH1A1 2507/4885MAPT 4732/4885KDM4E 2647/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.